OBJECTIVE: To evaluate the therapeutic efficacy of needle aspiration along with anti
amoebic drugs than anti amoebic drugs alone in Amoebic Liver abscess.
STUDY DESIGN: Comparative, Prospective.
PLACE OF STUDY: Medical Ward III, Chandka Medical College Hospital Larkana
from January 2006 to December 2007.
PATIENTS & METHODS: This comparative, prospective study was conducted in Medical
Unit-III CMC Hospital Larkana from January 2006 to December 2007. Total 52 patients
were included in this study and were divided into two groups. Group A, included 28
(53.84%) patients and comprised of patients having abscess cavity > 10 cm or smaller
abscess but not responding to medical treatment. They were given combined treatment
i.e. Needle aspiration along with medical treatment. Group B, comprised of 24 (46.15%)
patients who had abscess cavity < 10 cm and were given medical treatment alone. Main
outcome measures were abdominal pain, fever, hepatomegaly, resolution of Amoebic
Liver abscess on ultrasound, length of hospital stay and any complications, if occur.
Follow up was at least up to 06 months.
RESULT: Total of 52 patients were included in this study which were divided in two
groups. Group A consisted of 28 (53.84%) patients whereas Group B 24 (46.15%)
patients. The age ranged from 18-70 years (mean 42.61%). 42 (80.76%) patients were
male and 10 (19.23%) were females, male to female ratio was 4.2:1. 48 (92.23%)
patients had right lobe involvement while 04 (7.70%) had left lobe involvement. Needle
aspiration was successful in 26 (92.85 %) patients and failed to respond in 02 (7.14%)
patients. The mean time of clinical improvement was 5.5 and 08 days respectively in
group A and B. The hospital stay was shorter in group A than B. The resolution of
abscess cavity on ultrasound was rapid in Group A than B and there was no complication
CONCLUSION: It is concluded from this study that Needle Aspiration along with anti
amoebic drugs are superior than alone anti amoebic drugs for the management of