International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 5 Issue 6, September-October 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 946 A Critical Review on Brihat Kasturi Bhairav Rasa with Special Reference in Management of Jwara-A Herbomineral Formulation Dr. Sahana Santosh Shet 1 , Dr. Shankara Gowda 2 , Dr. Ravi R Chavan 3 1PG Scholar, 2Professor, 3HOD & Professor, 1,2,3Department of Rasashastra and Bhaishajyakalpana, Taranath Government Ayurveda Medical College and Hospital, Ballari, Karnataka, India ABSTRACT Introduction: Brihat Kasturi Bhairav Rasa is a Kharaliya Rasayana mentioned in Bhaishajya Ratnavali in Jwaradhikara. It consists of Kasturi (Jantavya dravya) as main ingredient & 17 other ingredients & Arka patra swarasa as bhavana dravya. A critical analysis is made to explore this unique Jwarahara Yoga of classics to unfold the Antiviral, Antipyretic, Antioxidant and Immunomodulatory potential of phytochemicals in the formulation. AIM: To critically Review the formulation Brihat Kasturi Bhairav Rasa and variants of Kasturi Bhairav Rasa. MATERIALS & METHODS: References of Brihat Kasturi Bhairav Rasa were collected from various available classical texts, some articles from various journals were also reviewed in this attempt. OBSERVATIONS & RESULTS: Swalpa Kasturi Bhairav Rasa,Madhyama Kasturi bhairav Rasa & Brihat Kasturi Bhairav Rasa three different formulations with Kasturi as main ingredient is mentioned in various classics & AFI accepted Brihat Kasturi Bhairav rasa with many bhasmas in it with unique indications. CONCLUSION: The review will definitely give new insights on the synergistic actions of phytochemicals in formulations to revalidate the clinical evidences and will throw lime light on repurposing of the documented novel drugs and combinations in classics to offer unique preventive strategies and therapeutic solutions to the present pandemic and emerging viral infections. KEYWORDS: Kasturi Bhairav Rasa, Kasturi (Jantavya dravya), Jwarahara Yoga, Immunomodulatory How to cite this paper: Dr. Sahana Santosh Shet | Dr. Shankara Gowda | Dr. Ravi R Chavan "A Critical Review on Brihat Kasturi Bhairav Rasa with Special Reference in Management of Jwara-A Herbomineral Formulation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6, October 2021, pp.946-953, URL: www.ijtsrd.com/papers/ijtsrd47513.pdf Copyright © 2021 by author (s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http: //creativecommons.org/licenses/by/4.0) INTRODUCTION Ayurveda is mother of all healing science. Rasashastra or the Ayurvedic alchemy is an important branch of Ayurvedic Pharmacology. This branch deals with the use of metals and minerals, gemstones & their processing. The minerals & metals are very effective & potent for immunization, Rejuvenation & the elimination of diseases. Rasashastra is the special science, which deals with the metallic, mineral & poisonous drugs. These drugs are pharmaceutically processed and rendered fit for internal administration. Rasoushadis are known for smaller dosage. They are palatable, provides quick results & cures difficult disease conditions. 1 Kasturi Bhairav Rasa is a brilliant formulation told in Bhaishajya Ratnavali in Jwaradhikara consisting Kasturi as its main ingredient, it takes care of ailments from fever & UTI to diabetes. It is potent Kharaliya Rasayana, Kasturi is Mrigamada which is obtained from animal origin (Jantavya Dravya). Hence its availability is difficult & very expensive. There are many references available for Kasturi Bhairava rasa in the classics. The AFI accepted the bhaishajya Ratnavali’s reference “” & Swalpa Kasturui Bhairava rasa”. Brihat Kasturi Bhairav Rasa is first mentioned in Rasa Ratnakar. This formulation is made up by 18 ingredients and one IJTSRD47513 International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 947 Bhavana dravya i. e., Arka Patra swarasa and numerous therapeutic value. Jwara is originated out of “rudrakopa” according to Ayurveda mythological history. Jwara is not just raised body temperature, but as per Charaka, ‘Deha- indriya -Manah Santap’ are the cardinal symptoms of Jwara. Hence it is most important among all other diseases. It diminishes the intelligence, strength, complexion & enthusiasm of the sufferer & produces exhausation exertion & aversion to food. In jwara due to shareerika doshas or manasika doshas vikriti & agni vikriti, ama is produced & it vitiates rasa dhatvagni causing avarodha of swedavaha srotas, leading to increased temperature. Jwara is said to be the first disease that occurs to humans. According to sushruta 2, a person enters and departs from earth with Jwara only. WHO’s Definition of health is “A state of complete physical, mental and social well-being, not merely the absence of disease and infirmity”3. One such disease is jwara, that causes Santapa (Pyrexia), Aruchi (Anorexia), Trishna (thirst), Angamarda (bodyaches), Hrdivyadha (distress in cardiac region)4. Jwara sthana is sarvashareera along with Manas, Jwara is characterized by excessive heat in the body as well as mind5 and line of treatment being focused on langhana 6. A Uttama Vaidya must have the knowledge on how the medicine is acting on the system based on his yukti, the contents of the formulation, and must know medicines pharmacokinetics and pharmacodynamics. Hence here is an attempt made to discuss the formulation Kasturi Bhairava Rasa which is mainly indicated in all types of Jwara. Whereas the contents in this particular medicine suggest that it can also be given in other diseases. Materials and Methods for Preparing Kasturi Bhairav Rasa: The name of the formulation suggests it contains Jantavya dravya Kasturi in it, it also suggests it cures Jwara by the name Kasturi Bhairava Ras where Bhairava is adhipati of Jwara. And three variants of Kasturi bhairava rasa is Brihat, Madhyama And Swalpa Kasturi Bhairava Rasa based on the number of ingredients present in it. Kasturi is the common ingredient in all the three variants. Based on this, it can be said that this particular formulation will be working on Jwaradhi vyadhis. Kasturi Bhairava Rasa is mentioned in different rasa classics like Bhaishajya Ratnavali, Rasa Ratnakar, Rasda Sudhakar, Rasa Chandamshu, Rasendra sara Sangraha, Dhanwantari Nighantu. There are 3 variants mentioned in the classics based on number of ingredients as Swalpa Kasturi bhairava Rasa, Madhyama Kasturi bhairava Rasa & Brihat Kasturi Bhairava Rasa. All the above 5 classics have mentioned Brihat Kasturi Bhairava rasa, whereas Rasendra sara Sangraha, Rasa Sudhakar and Dhanwantari Nighantu have explained Madhyama Kasturi Bhairava Rasa and Swalpa Kasturi Bhairava rasa. Table No. 1 showing Method of preparation of 3 variants of Kasturi Bhairava Rasa ingredients and indications: NAME OF FORMULATION REFERENCE MAIN INGREDIENT AND METHOD OF PREPARATION DOSE, INDICATION Swalpa Kasturi Bhairava Rasa (Jwara Rogadhikar) Rasendra Sara Sangraha, Rasarajasundara, Bhaishajya Ratnavali. Hingula, Shuddha vatsanabha, Shuddha Tankana, Jatikosha, Jatiphala, Maricha, Pippali, Kasturi all ingredients in equal quantity mixed and stored in air tight container. Dose-2 Ratti Indication- Sannipataja Jwara. Madhyama Kasturi Bhairava Rasa Rasendra Sara Sangraha, Rasarajasundara, Dhanwantari Vanga Bhasma, Karpara (Jashada Bhasma), Kasturi, Swarna Bhasma, Rajata Bhasma -all one tola each, Kantha Bhasma-1 pala, Parada Bhasma, Hemasara, Jatipala, Lavanga-2 tola each. All the ingredients are taken in a khalwa yantra & mardana is done to get the homogeneous mixture. Bhavana is done with Dronipushpi Swarasa and Nagavalli Swarasa for 7 days. Add 2 tola Karpoora and 2 tola Trikatu to this bhavita dravya. Prepare vatis of 3 ratti to 1 masha size each. Dose-3 ratti to 1 masha Indications: Vatolbana Sannipataja Jwara, Mahashwasha, Sleshma rogas, Tridosha janita Ghora sannipataja daruna, Nasta Garbha, Nasta Shukra, Vishama Jwara, Kasa, International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 948 Shwasa, Kshaya, Gulma, Maha Shotha, Mahagada, Prameha & Raja yakshma Brihat Kasturi Bhairava Rasa (Jwararogadhikara) Bhaishajya Ratnavali, Rasa Ratnakar, Rasarajasundara, Rasa Chandamshu, Rasendra sara Sangraha, Dhanwantari Kasturi, Karpura, Tamra Bhasma, Dhataki churna, Atmagupta Beeja Churna, Swarna Bhasma, Rajata Bhasma, Mukta Bhasma, Pravala Bhasma, Loha Bhasma, Pata Churna, Vidanga Churna, Mushta Churna, Shunti Churna, Sugandabala/Hrivera Churna, Shuddha Haratala, Abhraka Bhasma, Amalaki Swarasa, Bhavana Dravya -Arka patra Swarasa. All the ingredients taken in khalwa yantra and homogeneous mixture is made, to this Amalaki swarasa is added & Bhavana dravya Arka Patra swarasa is added and bhavana is done and vati of 1 ratti is prepared and stored well. Dose-1 ratti (125 mg) Indiactions- Atisara, Grahani, Jwara, Prameha, Amatisara The formulation of Brihat Kasturi Bhairava Rasa is selected for this study is from Bhaishajya Ratnavali- Jwaradhikara. This formulation is made up by 18 ingredients and one Bhavana dravya i. e., Arka Patra swarasa and numerous therapeutic value. Contents of the medicine: 5 This is a herbomineral preparation containing one Jantavya dravya, 8 mineral drugs calx, 9 herbal drugs, Ingredients as in Sl. No 3 in table no 1, which is given Bhavana with Arka Patra Swarasa. Table no 2, Showing the ingredients and botanical name, useful part of Brihat Kasturi Bhairava Rasa Sl. No Name of the Drug Botanical Name/Latin Name Useful Part Quantity 01 Kasturi (Musk) Moschus moschiferus Musk Pods 1 part 02 Karpura (Camphor) Cinnamomum Camphora Niryasa 1 part 03 Tamra Bhasma (Copper) Calx of Copper Calx 1 part 04 Dhataki Churna (Fire flame Bush) Woodfordia fruticosa Flower 1 part 05 Atmagupta Beeja Choorna (Velvet bean) Mucuna pruriens Seed (Beeja) 1 part 06 Swarna Bhasma Aurum (Au) Bhasma 1 part 07 Rajata Bhasma Argentum (Ag) Bhasma 1 part 08 Mukta Bhasma Pinctada Fucata Bhasma 1 part 09 Pravala Bhasma Corallium Rubrum Bhasma 1 part 10 Loha Bhasma Ferrum (Fe) Bhasma 1 part 11 Pata Churna (Velvet Leaf, Ice vine) Cissampelos pareria Patra, Mula 1 part 12 Vidanga Churna (False Black Pepper) Embelia ribes Fruit 1 part 13 Musta Churna (Nut Grass) Cyperus Rotandus Root 1 part 14 Shunti Churna (Ginger) Zingiber officinalis Rhizome 1 part 15 Sugandabala/Hrivera Churna Pavania Odorata Root 1 part 16 Shuddha Haratala (purified Orpiment) Arsenic trisuphide Bhasma 1 part 17 Abhraka Bhasma (Mica) Biotite Bhasma 1 part 18 Amalaki swarasa (Indian gooseberry) Emblica Officinalia Fruit 1 part 19 Bhavana dravya-Arka Patra Swarasa Calotropis Procera Patra Q. S Any formulation which is being developed needs a few things to be concentrated like Rasa Panchaka which are very much important for its Vyadhihara property. International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 949 Table no 3: Showing Rasa Panchaka of Brihat Kasturi Bhairava Rasa Sl. N o Dravya Rasa Guna Veery a Vipaka Karma Proven pharmacological activity 01 Kasturi Tikta, Kashaya Guru Ushna Katu Kapha Vata Shamaka, Sheeta Shamaka, Durgandha Hara, Shukravardhaka, Alakshmi Hara, netrya Antidepressent activity, Cardiotonic, Nervin tonic. 02 Karpoora Tikta, Katu, Madhura Laghu, Rooksha Sheeta Katu Kapha pitta hara Anti spasmodic, Anti Ibnflammatory, Anti septic, Cough supressant, Strong decongestant, Fungicide, Antiarthritic 03 Dhataki Kashaya Laghu, Rooksha Sheeta Katu Kapha Pitta hara, Sandhaneeya, Mutraviranjaniya, Pureeshsangreehniy a Immunomodulatory action, 04 Tamra Bhasma Kashaya, Madhura , Tikta, Amla Laghu, Rooksha Ushna Katu Kapha pittahara, Antiacid, Expectorant, Mild Laxative, Digestive stimulant, Emmenagogue, Heamatogenic, Lowers Bilirubin, Zinc antagonist. 05 Atmagupta Beeja Madhura , Tikta Guru, Snigdha Ushna Madhur a Tridoshahara, Balya, Vatasamshamana, Prabhava-Vrishya Aphrosidiac, Bulk enhancer 06 Swarna Bhasma Madhura , Kashaya Laghu Snigdha Sheeta Madhur a Tridoshaghna- visheshata pitta KshamakaVrishya, Balya, Rasayana, Hridya, Brihmana, Madhasmritiparam, Unmadahara Immunomodulator activity, Rejuvinatary action, Free radical scavenging activity, Anti cataleptic, Anti anxiety, Analgesic activity, Antioxidant 07 Rajata Bhasma Kashaya, Amla Snigdha, Lekhana Sheeta Madhur a Vata pittahara, Rasayana, Bhrama, Vrikshya, Medhya, Jwarghna Hypoglycemic effect, Anti fungal effect (Candida albicans), Antimicrobial Effect, Free radical scavenger, Anti depressant, Anti proliferative activity International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 950 08 Mukta Bhasma Madhura Laghu, Sheeta Sheeta Madhur a Kapha pittahara, Medhya, Netrya, Varnya, Agnipushtikara, Deepana, Pachana, Vrushya, Ayushya Aphrosidiac, GERD, Acid peptic disorders. 09 Pravala Bhasma Madhura , Amla, Kashaya Laghu, Snigdha Sheeta Madhur a Tridoshahara, Kapha vatahara, Ratri swedhaharaparam, Kantikara, Mangalakara, Balya Diabetic neuropathy, Hyperhydrosis 10 Loha BHasma Tikta, Kashaya, Madhura Guru, Rooksha Sheeta Madhur a Kapha pittahara Anti inflammatory, Hematonic 11 Patha Tikta, Katu Laghu, Tikshna Ushna Katu Tridoshaghna, Vajikara, Graahi, Asthisandhanaka, Raktashodaka, Sthanya shodhana. Aphrosidiac, Bone setting 12 Lavanga Katu, Tikta Laghu, Rooksha , Tikshna Ushna Katu Vata kaphahara, Vatanulomana, Deepana Antihelminthic 13 Mustha Katu, Tikta, Kashaya Laghu, Rooksha Sheeta Katu Kaphapittahara, Deepana, Grahi, Pachana, Tvachya, Lekhana Irritable bowel syndrome, Insomnia, Rheumatid arthritis 14 Shunti Katu Laghu, Snigdha Ushna Madhur a Kapha vatahara, Vatanulomana, Deepana, Hridya, Pachana Appetizer, Anti inflammatory 15 Sugandabal a Tikta Laghu, Rooksha Sheeta Katu Kapha pittahara, Deepana, Pachana Menorrhagia, Anti diarrhoeal 16 Shuddha Haratala Katu, kashaya, Tikta Snigdha Ushna Katu Vata kapahara, Tridoshaghna Skin tonic, Anti pyretyic 17 Abhraka Bhasma Kashaya, Madhura Slakshna Sheeta Madhur a Tridoshahara Reduces risk of hypertension, Cardiac diseases, IUGR, Osteoporosis, Aphrosidiac, Nervin tonic 18 Amalaki Swarasa Lavana varjita pancha rasa Laghu, Rooksha Sheeta Madhur a Tridoshaghna, Cakshusya, Vayasthapana, Vajikara, Rasayana Diabetes Mellitus Type2, Immunomodulatory , Anti oxidant 19 Arka Patra Swarasa Tikta, Katu Laghu, Snigdha, Sara Ushna Katu Vata kaphahara, Deepana, Bhedana, Ropana Wound healing International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 951 Method of preparation: 1 All the 17 ingredients in Table no 3 are taken in a khalva yantra and mardana is done to form a homogeneous mixture. To this mixture amalaki swarasa & arka patra swarasa is added and bhavana is done. Prepare vati s of 1 ratti each and dry in shadow & then store in glassware Indication-Various diseases related with Rasavaha Srotas, Shukravaha srotas, etc. are included in the indications. All the references of have mentioned Kasturi Bhairava Rasa in Jwara adhikara. Kasturi Bhairava Rasa is a Rejuvenating formulation having multidimensional action. It is indicated in all types of jwara, Vishama Jwara, Dwandwaja Jwara, Bhoutika Jwara, Kaamadi sambhav Jwara, Abhicharaja, Dakhinyadi Graha Sambhava Jwara is also cured by this formulation. Anupana Vishesha karma is attributed to this formulation with particular anupana it has particular indication. Anupana Vishesha: Bilwa churna [Aegle marmelos], Jeeraka churna & Madhu is taken as anupana in case of Amatisara, Grahani, Jwaratisra – diarrhea due to impaired digestion and metabolism Taken in Musta Kashaya [Cyperus rotendus] for grahani. Taken in Dashamoola – group of 10 roots, for atisara (diarrhea )and Jwara (fever). Taken in Shunti – ginger [Zingiber officinale] in case of all types of Jwara. Taken in Amalaki [Embelica officinale] fruit or Guduchi [Tinospora cordifolia] kashaya for prameha (diabetes) Or in other appropriate decoctions or arishtas for desired effect. Dose: 1 ratti MODE OF ACTION: Almost all ingredients of this yoga has jwarahara properties, Amapachana Karma & Agni deepana Qualities are inherent.
Most of the drug in this yoga are katu, Tikta, Kashaya rasa pradhana & Laghu rooksha, Tikshna Guna with sheeta veerya & Katu vipaka properties which has Tridoshara karma grossly Kapha vatahara Karma, Hence brings back Sthanachuta pitta to its Swasthana by pacifying prakupita Kapha and vata dosha.
The drugs in the Formulation as their Action on Swedavaha srotas, due to vyavayi & teekshna guna it cures Srotovarodha hence does sroto vishodana quickly and reduces jwara by sweda nirharana.
It also acts as agnideeptikara and does amadosha pachana & nirharana ‘Ama’ which is culprit to cause any disease basically. DISCUSSION: As per Ayurveda root cause of all diseases is due to Mandagni (weak digestive fire) and Ama (undigested material). Ama released various types of toxins which further suggest infective in origin. Atisar arises mainly due to Ama. Kasturi Bhairav Rasa mainly acts on Agni. It is said to be the first disease that occurs to humans. According to Aacharya Sushruta7, a person enters and departs from earth with Jwara only. Jwara is classified into many types based on the combination of doshas, They are 8 8, Sannipataja Jwara are again of 13 types9. All these jwara are having same poorvaroopa but different chikitsa sootras. Acharyas opine that all these kinds of jwara are curable only when they are in their Tarunavastha. Brihat Kasturi Bhairava Rasa is a Kharaleeya Rasayana which is explained in Bhaishajya Ratnavali Jwara Rogadhikara 10. The dravyas used in this preparation are having Jwaraghna properties which have been proved in different studies individually and also a Rasoushadis like Swarna bhasma, Rajata Bhasma, Tamra Bhasma, Abhraka Bhasma because of their Rasibhavanti properties21 will enter into the srotas and will directly work on the Hypothalamus which controls the body temperature and will help in reducing fever. In the same way these dravyas will also help in different ailments pertaining to respiratory tract where again dravyas help in curing different ailments like pneumonia, Bronchitis and other URTI. When it comes to Sirobhaaga, all dravyas will act according to their gunas i. e., laghu, teekshna, vyavayi, yogavahi, by which it can be claimed that they will enter into srotas and start their action in curing different ailments like Jwara, etc., also because of their action on CNS which has been in different studies. As we reviewed the properties of this both drugs mainly acts on Annavaha Srotas, Swedavaha Srotas, Jatharagni, Dhatvaagni. Atisar is mainly of Annavaha and Purishvaha Srotas Vyadhi. (11, 12, 13) Jwara is Annavaha and Sweda Vaha Srotas Vyadhi (disease) hence Anand Bhairav Rasa acts on this diseases specifically. Every formulation having its different Anupana because of which the Roghanta also get differs. In fact, Jwarahara Yogas of classics are designed in a unique way that the anti-inflammatory, anti-viral, antipyretic, antioxidant, immunomodulatory International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 952 potentials of drugs act in synergy to enhance the body’s overall natural resistance to the disease- causing agent rather than directly neutralizing the agent itself. (14) A thorough analysis of classics reveals that the fundamental principle of combating any form of Jwara is digesting the ama, preserving the agni, relieving Shrotorodha (Obstructive pathology occurring in channels) and inducing sweat which inturn brings down the temperature. Analysis of Antipyretic activity The essential elements of the fever physiologic pathway are release of pyrogenic cytokines by inflammatory cells in response to some exogenous pyrogen (e. g. infection), induction of cyclooxygenase (COX) 2 activation of the arachidonic acid cascade, and enhanced biosynthesis of prostaglandin E2 (PGE2) by hypothalamic vascular endothelial cells15. Through its effect on thermoregulatory neurons located in the preoptic area of the anterior hypothalamus, PGE2 acts to raise the hypothalamic thermal set point and thereby induce peripheral and thermogenic mechanisms to increase core temperature. Antipyretic agents might interrupt the fever response at any step along this pathway16. The antipyretic activity of various drugs may be attributed to the high content of flavonoids in drugs like Amrita (Tinospora cordifolia), Amalaki (Phyllanthus embelica), etc. by inhibiting prostaglandin synthesis in hypothalamus. A study reported that Quercetin may inhibit fever causing inflammatory mediators17. In a nutshell, the antipyretic action of drugs may be interpreted as follows. β-Sitosterol block the pathway of phospholipase and inhibit the production of arachidonic acid. Flavonoids and its related compounds block the action of Cyclooxygenase pathway and inhibit the production prostaglandins (PGE2) thus reducing the fever18. Analysis of Antiviral activity There are several mechanisms which govern the antiviral activity of phytochemicals. Inhibition of viral attachment 6-Shogoals, 6-Gingerol, Allicin of Ginger blocks viral attachment and internalization. Tinosporin of Heart Leaved Moonseed inhibit the virus from establishing infection to target the t helper cells19 Therefore jwaraghna dravye should act on rasavaha and swedavaha strotas. It should acts as agnideepan. Therefore snigdha, ushana, laghu dravye can be used in jwar but as for doshprakop, Madhur, tikta rasa dravye can be used in Jwara. many jwaraghna dravya has mentioned in Ayurveda Some acts as santaphar, some by doing aampachan, some by doing dahaprashman. Some drug reduces temp, some does vasodilation, some acts on hypothalamus, or some makes sweating and reduces fever. PATHA -Cissampelos Pariera Linn. – Menispermeaceae It has tikta rasa, ushna veerya, katu vipak. According to Bhavprakash Nighantu, It acts as vatkaphahar. It can be used in fever, vomiting and diarrhoea. Due to its tikta rasa and ushn veerya, it acts as aamdoshhar and jwaraghna. Being febrifuge and refrigerant, it can be used in fever and its related burning disorder. Some study shows antipyretic and analgesic effect observed in Cissampelos Pariera Linn20. AAMALAKI - Emblica Officinalis - Euphorbiaceae. It has rasayana property. It means it increases dhatubal and can be used in chronic fever. It has antipyretic and analgesic activity. This is due to presence of tannin alkaloids, phenolic compounds, carbohydrates and amino acids. [21] Aamalaki exhibits strong antioxidant activity. It has immunomodulatory Action and antiinflammatory action. [22] Since flavonoids well known for their ability to inhibit pain perception and to exhibit antiinflamatory properties due to their inhibitory effects of chemical mediator of inflammation. Flavonoids and its related compound also exhibit inhibition of archnoidacid Peroxidation which results in reducing prostaglandin levels thus reducing the fever. [23] Antioxiant activity of Flavonoids - Flavonoids represent a large group of Low molecular weight compounds with high antioxidant properties. Their specific Chemical structure allows them to reduce oxidative stress through numerous mechanism. Flavonoids could act both preventive antioxidant and chain breaking antioxidants. [24] CONCLUSION: Brihat Kasturi Bhairava Rasa is first mentioned in Rasa Ratnakar. is very potent formulation which is widely open to work for further research which is now widely used in different types of jwara, amaatisara, shosha. Kasturi is very expensive and difficult to procure hence alternative to it can be researched by the researchers for further use without harming ecological balance. The review will give new insights on the synergistic actions of phytochemicals in formulations to revalidate the clinical evidences and will throw lime light on repurposing of the documented novel drugs and combinations in classics to offer unique preventive strategies and therapeutic solutions to the present pandemic and emerging viral infections. International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD47513 | Volume – 5 | Issue – 6 | Sep-Oct 2021 Page 953 REFERENCES: [1] SriGopal Krishna: Rasendra sara sangraha; Rasachandrika commentary by Pt Girijadayalu Shukla; Chapter no 1, Verse 4; Chaukhambha Amarabharathi Prakashana, Varanasi: 1981: 6th Edition, pp-2. [2] Sushruta Samhita, Edited by G. D. Singhal, 2nd Edition, Delhi, Chaukhambha Sanskrit Pratisthan, 2007, 39th chapter, Verse 10, 203pp. [3] https: //healthy-talks. com/defination-of-health- according-to-who/ [4] Agnivesha, Charaka Samhita, Ayurveda Dipika Ayushi Hindi Commentary by Chakrapanidatta, edited by Vd. Harish Chandra Singh Kushwala, reprint Varanasi, Chaukhambha Orientalia, 2012. 3rd Chapter Chikitsa Sthana, Verse 26, 73pp. [5] Agnivesha, Charaka Samhita, Ayurveda Dipika Ayushi Hindi Commentary by Chakrapanidatta, edited by Vd. Harish Chandra Singh Kushwala, reprint Varanasi, Chaukhambha Orientalia, 2012. 3rd Chapter Chikitsa Sthana, Verse 30-31, 74pp. [6] Sushruta Samhita, Edited by G. D. Singhal, 2nd Edition, Delhi, Chaukhambha Sanskrit Pratisthan, 2007, 39th Chapter, Verse 100, 216pp. [7] Sushruta Samhita, Edited by G. D. Singhal, 2nd Edition, Delhi, Chaukhambha Sanskrit Pratisthan, 2007, 39th Chapter, Verse 10, 203pp. [8] Sushruta Samhita, Edited by G. D. Singhal, 2nd Edition, Delhi, Chaukhambha Sanskrit Pratisthan, 2007, 39th Chapter, Verse 14, 203pp. [9] Agnivesha, Charaka Samhita, Ayurveda Dipika Ayusi Hindi Commentary by Chakrapanidatta, edited by Vd. Harish Chandra Singh Kushwala, reprint Varanasi, Chaukhambha Orientalia, 2012, 3rd Chapter Chikitsa Sthana, Verse 32-35, 75pp. [10] Sen Govind Das. Bhaishajya Ratnavali (Siddhiprada hindi commentary) of Prof. Mishra Siddinandana. 1st Edition. Varanasi: Chaukhamba Surabharati Prakashan; 2015. th Chapter; Verses 55-59, 1130pp. [11] Savita Saini, Sharad Porte, Antimicrobial rasa (atisar adhikar) on stock enteropathogenic bacteria w. s. r to bacterial food poisoning wjps 2016; page no 460-463. [12] Savita Saini, Sharad Porte, In vitro antibacterial study of Anandbhairav Rasa by self created poisoning ejpmr 2016. [13] Savita Saini, Sharad Porte, Antimicrobial properties of Anand Bhairav Rasa and its ingredients: an overview ijrap 2015. [14] www.ijrap.net (ISSN: 2229–3566) a critical review of jwarahara yogas of ayurvedic classics: a paradigm to reverse pharmacology [15] Mackowiak PA. Concepts of fever. Archives of Internal Medicine 1998; 28, 158 (17): 1870-81. [16] Grundmann, M. Studies on the action of antipyretic substances. Diss. University of Oxford; 1969. [17] Hämäläinen, Mari, et al. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin and pelargonidin inhibit only NFκB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators of inflammation; 2007. [18] Baumann, J. , F. V. Bruchhausen, and G. Wurm. Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation. Prostaglandins 1980; 20. 4: 627-639. [19] Ramàkrishnamacharya CH, Vanitha Muralikumar, and Chandrasekar Seshachalam. Inhibitory Effect of Phytochemicals from Azadirachta indica A Juss. and Tinospora cordifolia (Thunb. ) Miers against SARS-CoV- 2 M pro and Spike Protease-An in-silico Analysis. Science Open Preprints; 2020. [20] Singh SG, Nishtewswar k - Comparative antipyretic and analgesic activities of Cissampeloes Pariera Linn. and Cyclea Peltata (Lam) Hook. F and Thomas. An international journal of Research in Ayurveda, 2016; 37 (1): 62 -66. www.ayujournal. [21] Perinayagam JB etal- Evaluation of antioyretic and analgesic activity of emblica officinalis Gaertn. - J. Ethnopharmacol, 2004 nov; 95 (1): 83-5. [22] Kishwar Hayat Khan – Role of Emblica officinalis in Medicine – A review. october 2009 [23] Mradu Gupta et al. - A new glycosidic flavonoid from jwarhar Mahakashay (antipyretic) - Ayurvedic preparation. International Journal of Ayurveda research, 2010; 1 (2): 106 -111. [24] Vasai Georgiev et al. - Recent advances and uses of Grape Flavanoids As nutraceuticals, 2014; 6 (1): 391- 452.