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International Journal of Biological & Medical Research
Int J Biol Med Res. 2010; 1(3): 71-73.
Effect of
leaves on serum lipids in ammonium chloride induced
experimental hyperammonemic rats
Pongamia pinnata
Mohamed M. Essa * Amanat A. Ali , Mostafa I. Waly , Gilles J Guillemin , P. Subramanian
a,b,c
a
a
b
d
A R T I C L E I N F O
A B S T R A C T
a
b
c
d
Dept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Oman
Neuropharmacology group, Dept of Pharmacology, College of Medicine, University of New South Wales, Sydney, Australia
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
Developmental Neuroscience Lab, NYSIBR, 1050 Forest Hill road, Staten Island, NY, 10314, USA
Keywords:
Original article
Hyperammonemia
Cholesterol
Ammonia
Triglycerides
Phospholipids
Free fatty acids
Pongamia pinnata
1. Introduction
Effect of
(an indigenous plant used in Ayurvedic Medicine in India) leaf
extract (PPEt) on the levels blood ammonia, and serum lipid profiles (cholesterol, triglycerides,
phosphor lipids, free fatty acids) were studied for its protective effect during ammonium
chloride induced hyperammonemia in Wistar rats. Ammonium chloride (AC) treated rats
showed a significant increase in the levels of circulatory ammonia and lipid profiles. These
changes were significantly decreased in PPEt and AC treated rats. Our results indicate that PPEt
offers protection by influencing the levels of ammonia and lipid profiles in experimental
hyperammonemia and this could be due to its (i) ability to detoxify excess ammonia, urea and
creatinine, (ii) free radical scavenging property both in vitro and in vivo by means of reducing
lipid peroxidation and the presence of natural antioxidants. Hence, it may be concluded that
the hypolipidaemic and antihyperlipidaemic effects produced by the PPEt may be due to the
pres