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Lead optimization is a diversified operation in drug discovery, in which
the chemical structures of compounds...
Lead optimization is a diversified operation in drug discovery, in which the chemical structures of compounds or
biologics are modified to improve target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and
toxicological properties to generate preclinical drug candidates. In order to understand the need for lead
optimization, it is important to determine the basic characteristics of leads, and in order to make a compound a
drug sample, at least five basic attributes need to be considered including potency, bioavailability, duration,
safety, and pharmaceutical acceptability.
BOC Sciences provides lead optimization to meet the minimum acceptance criteria of five basic attributes for a
successful clinical drug candidate.
Potency is the intrinsic ability of a compound to produce a desirable pharmacological response usually
measured via high throughput in vitro screens. In the field of pharmacology, potency is a measure of the
activity of a drug expressed in terms of the amount required to produce a given intensity effect. In
pharmacology, high potency usually means that a drug works since it makes the receptor metabolize the
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Lead optimization by BOC Sciences is achieved through the assay development and screening, computer-aided
drug design, and pharmaceutical science. And our experts have extensive experience in solving the problems in