LOAN AND SECURITY AGREEMENT
This modification, effective September 10, 2001, to the Loan and Security Agreement ("Agreement") effective
June 10, 1999, as amended, between OSTEOTECH, INC., a Delaware Corporation; OSTEOTECH
INVESTMENT CORPORATION, a New Jersey Corporation; CAM IMPLANTS, INC., a Colorado
Corporation; OSTEOTECH, B.V., H.C.
IMPLANTS, B.V., CAM IMPLANTS, B.V., OSTEOTECH/CAM SERVICES, B.V., each a Company of
The Netherlands; and OST DEVELOPPEMENT, a Corporation of France (jointly and severally "Borrower")
and FLEET NATIONAL BANK, Successor in Interest to Summit Bank ("Lender") and to which Agreement
these presents are so firmly affixed as to become a part thereof.
Notwithstanding anything to the contrary set forth in the Agreement, the Agreement is hereby amended as
1. The "DEFINITIONS" section is hereby amended by the addition of the following:
"Banking Day" - as defined in Section 11.6(d)
"LIBOR Rate (Equipment)" - as defined in Section 1.4(c)
"Prime Rate" - as defined in Section 1.4(g)
2. All references in the Agreement to "Base Rate" are hereby amended to refer to the "Prime Rate."
3. Paragraph 1.4(c) is hereby amended to read as follows:
1.4(c) Interest accrues on Loan III at Borrower's option, at either
(i) Lender's floating Prime Rate minus one-half of one percent (1/2%) per annum or (ii) the LIBOR Rate, as
selected by the Borrower during the initial monthly interest only payable period. Upon conversion pursuant to
Section 1.3(b) above, interest accrues at Borrower's option at either (i) Lender's floating Prime Rate or (ii) the
30, 60, 90 or 180 day Base LIBOR (London Interbank Offered Rate) plus 225 basis points [the "Libor Rate
(Equipment)"] as selected by the Borrower.
4. Paragraph 1.4(g) is hereby amended to read as follows:
The Prime Rate of Lender means the fluctuating Prime Rate of interest established by Fleet National Bank from
time to time whether or not such rate shall be otherwise published. Th