Arvind G. Bhagwat, Paul Wentworth and Patrick E. Conen
Pathologic and Experimental Study
Pulmonary Alveolar Proteinosis in Childhood: A
Desquamative Interstitial Pneumonia and
Observations on the Relationship of
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Observations on the Relationship of Desquamative
Interstitial Pneumonia and Pulmonary Alveolar
Proteinosis in Childhood: A Pathologic
and Experimental Study*
Arcirirl 6. Bhngtrat, J1.D ". Paul ll'er~trcortl~.
11.D t. orid
Pntrick E Conet%. J1.B.B.S.'
T?pical cases of desquamative interstitial pneumonia (DIP) and pulmonaq
alveolar proteinosis (PAP) in children ha\e been compared with (a) a problem
case which apparentl) showed features of both and @) with similar appearances
Induced in rabbit lungs. On the bask of this comparison we suggest that DIP
and PAP ma1 hare a common pathogenesis or that the) ma) represent different
stages or components of a single disease. Our experimental studies and the
evidence of other workers seem to indicate pre%ious sensitization to an un-
known agent to be an important factor in determining which components of
the disease process will dominate.
unusual case wit11 typical cases of DIP and P.%P
ulmonnry alveolar proteinosis ( P.\P