FIRST AMENDMENT TO LEASE
I. PARTIES AND DATE
THIS FIRST AMENDMENT TO LEASE (this "Amendment") dated for reference purposes only as of June 27,
2001, is entered into by and between ALTON PLAZA PROPERTY, INC., a Delaware corporation ("Lessor"),
and ISTA PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Advanced Corneal
Systems, Inc.) ("Lessee").
A. Lessor's predecessor in interest, Aetna Life Insurance Company, and Lessee entered into that certain Lease
Agreement dated September 13, 1996 (the "Lease") for certain premises located at 15279 Alton Parkway, Suite
100, Irvine, California 92618 (the "Premises"). The Premises contain approximately 13,448 square feet of
rentable area. The term of the Lease is currently scheduled to expire on September 30, 2001 (the "Term
Expiration Date"). Capitalized terms used and not otherwise defined in this Amendment shall have the same
definitions as set forth in the Lease.
B. Lessor and Lessee have agreed to extend the term of the Lease for an additional period of three (3) years
beyond the Term Expiration Date.
III. LEASE EXTENSION
Lessor and Lessee hereby agree to extend the term of the Lease upon the terms and conditions hereinafter set
A. Term. The term of the Lease is hereby extended for a period of three
(3) years commencing on October 1, 2001 and terminating on September 30, 2004 (the "Extended Term").
B. Rent. Notwithstanding any provision of the Lease to the contrary, Lessee shall pay to Lessor throughout the
Extended Term, at such place as Lessor may designate, without deduction, offset, prior notice or demand, Base
Rent in lawful money of the United States in the amounts as set forth below:
In addition, Lessee shall continue to pay throughout the Extended Term Lessee's Share, which is 6.24%, of the
Operating Expenses, Tax Expenses and Common Area Utility Costs in accordance with the terms of the Lease.
C. Condition of Premises. Lessee shall accept the Premises i