Demerol® (meperidine hydrochloride, USP)
WARNING: May be habit forming
Meperidine hydrochloride, a white crystalline substance with a melting point of 186° C to 189°
C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution
is not decomposed by a short period of boiling.
The oral solution is a pleasant-tasting, nonalcoholic, banana-flavored solution containing 50 mg
of DEMEROL, brand of meperidine hydrochloride, per 5 mL teaspoon (25 drops contain 13 mg
of DEMEROL). The tablets contain 50 mg or 100 mg of the analgesic.
Inactive Ingredients - TABLETS: Calcium Sulfate, Dibasic Calcium Phosphate, Starch, Stearic
Acid, Talc. ORAL SOLUTION: Benzoic Acid, Flavor, Liquid Glucose, Purified Water,
Chemically, DEMEROL is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester,
hydrochloride and has the following structure:
Meperidine hydrochloride is a narcotic analgesic with multiple actions qualitatively similar to
those of morphine; the most prominent of these involve the central nervous system and organs
composed of smooth muscle. The principal actions of therapeutic value are analgesia and
There is some evidence which suggests that meperidine may produce less smooth muscle spasm,
constipation, and depression of the cough reflex than equianalgesic doses of morphine.
Meperidine, in 60 mg to 80 mg parenteral doses, is approximately equivalent in analgesic effect
to 10 mg of morphine. The onset of action is slightly more rapid than with morphine, and the
duration of action is slightly shorter. Meperidine is significantly less effective by the oral than
by the parenteral route, but the exact ratio of oral to parenteral effectiveness is unknown.
INDICATIONS AND USAGE
DEMEROL is indicated for the relief of moderate to severe pain.
DEMEROL is contraindicated in patients with hypersensitivity to meperidine.
Meperidine is contraindicated in patients w