<p>Tags: HD, glutathione peroxidase,cells
A New Molecules That Can Prevent Huntington’s Disease
Was Found by Scientists
Huntington’s disease (HD) is a fatal neurodegenerative disease, which is
an inherited disease, and the patient's cells make a harmful substance
called Huntington’s protein wrongly. Theses abnormal proteins
accumulate into pieces, damage part of brain cells, especially those cells
related to muscular control, which will lead to uncontrolled twitch, and
patients could be able to develop dementia. And there is no good medical
treatment in medical field currently.
But now, researchers, from Department of Genetics at University of
Leicester, found a new potential therapeutic target of the disease. They
proved that glutathione peroxidase can serve as guardian of the neurons
in HD model animals. In this study, the researchers first found that the
enzyme can protect cells in yeast. They proved that the enzyme can
inhibit the progress of HD in multiple systems of baker’s yeast,
drosophilae and cultured mammalian cells respectively.
Researchers discovered many potential genes that can protect HD
diseases by genome-wide scan firstly. And then they did further
experiments in drosophilae and mammalian cells, they finally found that
glutathione peroxidase activity protect the model animals from HD
More importantly, drugs similar to the enzyme activity have been
conducted in clinical trials to treat other diseases, which also demonstrate
that the drugs may have therapeutic effect on HD.
The researchers point out that in addition to glutathione peroxidase, they
also found a lot of related genes of HD, and these genes have an
important significance in understanding the onset process of HD.
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