Dated October 16th, 2002
ARDANA BIOSCIENCE LIMITED
COLUMBIA LABORATORIES (BERMUDA), LTD.
COLUMBIA LABORATORIES, INC.
LICENSE AND SUPPLY AGREEMENT
[***] A CONFIDENTIAL PORTION OF THE MATERIAL HAS BEEN OMITTED AND FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.
LICENSE AND SUPPLY AGREEMENT, dated as of October 16th, 2002, between ARDANA
BIOSCIENCE LIMITED, a company incorporated in England, with its registered office c/o Dundas & Wilson
CS, Bush House, Aldwych, London WC2B 4PA, England ("Ardana") and COLUMBIA LABORATORIES
(BERMUDA), LTD., a Bermuda corporation, having its office at Rosebank Center, 14 Bermudiana Road,
Pembroke, HM08 Bermuda ("Columbia") and COLUMBIA LABORATORIES, INC., a US corporation
incorporated in Delaware having its principal place of business at 220 S. Orange Avenue, Livingston, NJ 07039
A. Columbia and its Affiliates (as hereafter defined) are engaged in, among other things, the research,
development, manufacture, marketing, distribution and sale of drug products in Europe, the United States, and
throughout the world.
B. Ardana is engaged in, among other things, the research, development, marketing, distribution and sale of drug
products in the Territory (as hereafter defined).
C. Columbia is the owner of certain Patent Rights, Trademarks and Regulatory Applications (as hereafter
defined) relating to the Product (as hereafter defined).
D. It is intended that Columbia UK (as hereafter defined) shall file the European Regulatory Application (as
hereinafter defined) relating to the Product and shall transfer the MAs (as hereafter defined) resulting from the
same to Ardana upon receiving Regulatory Approval.
E. Columbia is willing to grant to Ardana a license in the Territory and to supply Ardana with its requirements of
Finished Product (as hereafter defined) for this purpose and Ardana desires to acquire such license and to buy
such Finished Products upon and subject to the terms and conditions