• BASIC RESEARCH •
Efficacy of Chinese medicine Yi-gan-kang granule in prophylaxis
and treatment of liver fibrosis in rats
Xi-Xian Yao, Shu-Lin Jiang, You-Wei Tang, Dong-Mei Yao, Xin Yao
ELSEVIER
PO Box 2345, Beijing 100023, China World J Gastroenterol 2005;11(17):2583-2590
www.wjgnet.com
World Journal of Gastroenterology ISSN 1007-9327
wjg@wjgnet.com © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Xi-Xian Yao, Shu-Lin Jiang, You-Wei Tang, Dong-Mei Yao,
Xin Yao, Department of Gastroenterology, Second Hospital, Hebei
Medical University, Shijiazhuang 050000, Hebei Province, China
Supported by the Natural Science Foundation of Hebei Province,
No. 300358
Correspondence to: Professor Xi-Xian Yao, Department of
Gastroenterology, Second Hospital, Hebei Medical University,
Shijiazhuang 050000, Hebei Province, China. yaoxixian@163.com
Telephone: +86-311-7814356
Received: 2004-08-31 Accepted: 2004-09-03
Abstract
AIM: To investigate the efficacy of a Chinese medicine,
Yi-gan-kang granule (granules for benefiting the liver), in
prophylaxis and treatment of liver fibrosis in rats and its
possible mechanism.
METHODS: One hundred and forty Sprague-Dawley rats
were randomly divided into seven groups (20 each): group 1,
blank control group without any interference during the study;
group 2, CCl4-induced liver fibrosis group; group 3, pig
serum-induced liver fibrosis group; group 4, prophylaxis
group of CCl4-induced liver fibrosis by Yi-gan-kang; group 5,
prophylaxis group of pig serum-induced liver fibrosis by
Yi-gan-kang; group 6, treatment group of CCl4-induced liver
fibros