CONFIDENTIAL
AMENDED AND RESTATED
RESEARCH, DEVELOPMENT AND MARKETING
COLLABORATION AGREEMENT
DATED AS OF MAY 2, 1995
BETWEEN
ONYX PHARMACEUTICALS, INC.
AND
WARNER-LAMBERT COMPANY
TABLE OF CONTENTS
PAGE
ARTICLE 1. DEFINITIONS. . . . . . . . . . . . . . . . . . . . . . 1
ARTICLE 2. RESEARCH PROGRAM . . . . . . . . . . . . . . . . . . . 5
2.1 Undertaking and Scope. . . . . . . . . . . . . . . . . . . 5
2.2 Personnel and Resources. . . . . . . . . . . . . . . . . . 6
2.3 Term of the Research Collaboration . . . . . . . . . . . . 7
2.4 Rights to Know-How and Patents for Research. . . . . . . . 7
2.5 Collaboration Expenses . . . . . . . . . . . . . . . . . . 7
ARTICLE 3. COMMITTEES . . . . . . . . . . . . . . . . . . . . . . 7
3.1 Research Management Committee. . . . . . . . . . . . . . . 7
3.2 Marketing Committee. . . . . . . . . . . . . . . . . . . . 8
3.3 Meetings . . . . . . . . . . . . . . . . . . . . . . . . . 8
3.4 SAB Attendance . . . . . . . . . . . . . . . . . . . . . . 8
ARTICLE 4. PATENTS, KNOW-HOW, RIGHTS AND INVENTIONS . . . . . . . 9
4.1 Rights to Inventions . . . . . . . . . . . . . . . . . . . 9
4.2 Joint Inventions . . . . . . . . . . . . . . . . . . . . . 9
4.3 Protection of Patent Rights. . . . . . . . . . . . . . . .10
4.4 Allegations of Infringement by Third Parties . . . . . . .10
ARTICLE 5. DESIGNATION OF LEAD COMPOUNDS AND MARKETING RIGHTS . .11
5.1 Designation of Lead Compound . . . . . . . . . . . . . . .11
5.2 Collaboration Product. . . . . . . . . . . . . . . . . . .11
5.3 Independent Development. . . . . . . . . . . . . . . . . .11
5.4 Warner's Re-engagement Option. . . . . . . . . . . . . . .12
ARTICLE 6. LICENSES AND ROYALTIES . . . .