Vol.9, No.4 , 2009 •The Journal of Applied Research.
KEY WORDS: Cisapride, Efficacy,
Gastroesophageal reflux, and
Background: Gastroesophageal reflux is a
common problem in children, and (Gastro-
esophageal reflux disease) GERD comprises
its objective pathologic sequelae, but the
term has also been used more recently to
denote symptoms affecting quality of life.
The Clinical presentation is very variable.
It causes mortality and morbidity without
appropriate treatment plan.
Objective: We are going to evaluate the
efficacy of cisapride and metoclopramide
in children with gastroesophageal reflux
(GERD). In addition, these patients were
followed carefully for serious adverse drug
Material and methods: The current pro-
spective study was performed from De-
cember 2005 to March 2007 in Children’s
hospital medical center, involving 130
patients who diagnosed as GERD and their
ages were between 1 month to 12 years;
they were selected for prokinetic therapy.
The response to treatment was evaluated by
symptom improvement, and serious adverse
drug reaction was demonstrated.
Findings: The patients were divided into
two groups. The first group was included
104 cases (68 female and 36 male) received
cisapride(0.6 mg/kg/day divided in 3 doses
in liquid form), and the second group, ( 13
female and 13 male),26 patients, were treat-
ed with metoclopramide( 1mg/kg/day di-
vided in 3 doses in drop form). There was no
statistical significant difference for absence
or presence of esophagitis and it’s severity
in endoscopic and histologic examinations
between two groups. As a matter of fact,
almost 70% of the cases were treated with
acid-lowering agents simultaneously. In the
first group, ECG was recorded before treat-
ment as well as 48-72 hours and 12 weeks
after treatment. ECG showed Q-Tc interval
prolongation in 4.8% of the first group 48-72
hours after treatment. Moreover, we ob-
Efficacy and Side Effects of Cisapride and
Metoclopramide in Children wit