OBJECTIVE: The management of hepatocellular carcinoma is influenced not only by
the tumour status and underlying liver function but also by any comorbid illness in the
patients and diabetes mellitus is one of them. The present study was undertaking to
evaluate the effect of diabetes mellitus on hepatocellular carcinoma.
STUDY DESIGN: Observational descriptive study.
PLACE AND DURATION: This study was conducted in the department of Medicine
Liaquat University Hospital and Isra University Hospital, Hyderabad from November
2005 to October 2008.
MATERIAL AND METHODS: Total of 200 patients of HCC were analyzed. They were
divided into two groups with and without diabetes mellitus. Clinical status and laboratory
findings were noted and patients were followed for one year to see the prognosis in both
RESULTS: There were 200 patients in this study with mean age + SD of the patients
were 53.70 + 12 years. Amongst all cases of HCC 165(85.57%) were males and 35(17.0%)
were females, 46(23.0%) were diabetic and 154(77.0%) were non diabetic. Alfa fetoprotein
level was compared between two groups and we found that alfafetoprotein level was
2737.84+4149.564 ng/L in diabetics group whereas it was 11827.31+29287.392 ng/L in
non-diabetics group (P = 0.03) which is statistically significant. In diabetic group one
year mortality was 68.42% whereas in non diabetic group one year mortality was 45.23%(P
CONCLUSION: The overall survival rate in diabetic group was significantly lower than
those the in non-diabetic group. Alpha fetoprotein level was significantly low in diabetic
than in non-diabetic group.
KEYWORDS: Hepatocellular carcinoma, Diabetes Mellitus, Alfa fetoprotein
The incidence of hepatocellular carcinoma has increased significantly over the past decades
in many parts of the world. An estimated 600,000 new cases are diagnosed annually of
which 82% are from developing countries.(1) The incidence of hepatocellular carcinoma
varies according to the prevalence of hepatitis B and C infecti