AMENDMENT NO. 1
to the Collaborative Agreement
dated as of April 19, 1995
between Novartis Pharma AG and
OSI Pharmaceuticals, Inc.
Novartis Pharma AG of Lichtstrasse 35, CH-4002 Basel, Switzerland and OSI Pharmaceuticals, Inc., of 106
Charles Lindbergh Boulevard, Uniondale, New York 11553-3649, USA agree to amend the above mentioned
agreement (hereinafter referred to as "1995 Agreement") as follows:
The four year time limit to exercise the option set forth in Section 5.7 of the 1995 Agreement will be extended
until the end of May and such option right will therefore not expire until May 31, 1999.
BASEL April 13, 1999 UNIONDALE April 13, 1999
Novartis Pharma AG OSI Pharmaceuticals, Inc.
/s/ /s/ /s/
Dr. I. Csendes G. Schelling Dr. C. Goddard
Head Licensing Drug Delivery Legal Counsel Vice President,
& Out-Licensing Business Development