Quick slow drug delivery system involves the use of compressed core, consisting of sustained release tablet, which is coated by compression over the whole surface with fast dispersible formulation. Propranolol hydrochloride, a non selective beta adrenergic blocker has widely used in the treatment of hypertension and angina pectoris with frequent administration. Aim of present study was to develop press coated tablet system to achieve quick slow release of the drug are the main purposes of biphasic drug delivery system to avoid frequent administration with increasing patient compliance and therapeutic efficacy. In this study immediate layer which was prepared using croscarmellose sodium, crospovidone and sodium starch glycol ate which was compressed on core tablet prepared by using HPMC and Ethyl cellulose. Results showed that the immediate layer dissolved within four minutes and core tablet releases drug for 12 hrs in controlled manner with zero order release kinetics. Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza "Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd38190.pdf Paper URL : https://www.ijtsrd.com/pharmacy/other/38190/formulation-and-development-of-modified-release-biphasic-compressed-tablet-of-propranolol-hydrochloride/mrs-poonam-jaykar-patil
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 5 Issue 1, November-December 2020 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD38190 | Volume – 5 | Issue – 1 | November-December 2020
Page 1375
Formulation and Development of Modified Release Biphasic
Compressed Tablet of Propranolol Hydrochloride
Mrs. Poonam Jaykar Patil1, Dr. Durgacharan A. Bhagwat2,
Ms. Rutuja Rajendra Shah3, Dr. Jhon I. D’souza4
1Gahlot College of Pharmacy, Navi Mumbai, Maharashtra, India
2Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India
3Anandi College of Pharmacy, Kalambe Tarf Kale, Kolhapur, Maharashtra, India
4Tatyasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India
ABSTRACT
Quick/slow drug delivery system involves the use of compressed core,
consisting of sustained release tablet, which is coated by compression over the
whole surface with fast dispersible formulation. Propranolol hydrochloride, a
non-selective beta-adrenergic blocker has widely used in the treatment of
hypertension and angina pectoris with frequent administration. Aim of
present study was to develop press-coated tablet system to achieve
quick/slow release of the drug are the main purposes of biphasic drug
delivery system to avoid frequent administration with increasing patient
compliance and therapeutic efficacy. In this study immediate layer which was
prepared using croscarmellose sodium, crospovidone and sodium starch
glycol ate which was compressed on core tablet prepared by using HPMC and
Ethyl cellulose. Results showed that the immediate layer dissolved within four
minutes and core tablet releases drug for 12 hrs in controlled manner with
zero order release kinetics.
KEYWORDS: Biphasic release; multiple unit dosage form; compressed tablets;
Tablet characteristic, Tablet dissolution
How to cite this paper: Mrs. Poonam
Jaykar Patil | Dr. Durgacharan A. Bhagwat
| Ms. R