Moore and J. A. Kaye
S. Adak, K. Illouz, W. Gorman, R. Tandon, E. A. Zimmerman, R. Guariglia, M. M.
Predicting the rate of cognitive decline in aging and early Alzheimer disease
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at Washington University on September 14, 2006
Predicting the rate of cognitive decline in
aging and early Alzheimer disease
S. Adak, PhD; K. Illouz, MS; W. Gorman, MS; R. Tandon, MS; E.A. Zimmerman, MD; R. Guariglia, BSN;
M.M. Moore, BS; and J.A. Kaye, MD
Abstract—Objectives: To determine prognostic factors affecting the course of Alzheimer disease (AD) and to determine
the role of region-specific brain volumes as predictors of cognitive decline. Methods: Longitudinal data from 166 normal
elderly individuals and 59 early AD patients were analyzed. Brain volumes were extracted from MRI scans using
semiautomated recursive segmentation methods. Prognostic factors were considered significant if they had a significant
effect on the rate of cognitive decline. Results: In multivariate analysis, higher Clinical Dementia Rating Scale (CDR)
score at entry was a significant prognostic factor for an increased rate of cognitive decline. Significant prognostic factors
within the baseline CDR 0 group were base rate of progression and percent total high signal intensity (HSI), percent
ventricular, and percent CSF volumes. Base rate of progression, family history, and percent ventricular volume were
significant prognostic factors within the CDR 0.5 group and APOE had a marginally significant effect on the rate of