An overview of the toxicity measurement, involving the importance of toxicity measurement, toxicity measurement analysis parameters and methods, and service features.
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CD Bioparticles now provide various strategies for drug toxicity study. Our
experienced scientists are dedicated to work on efficient and economically
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the toxicity of drugs loaded in different bioparticles.
Toxicity Measurement Introduction
Nanoparticles are used as carriers for drug delivery, and their own safety to
organisms or cells is receiving increasing attention. As a drug carrier, in
addition to the nature of the carrier, it also has less toxicity to the organism. In
this way, the side effects of the drug carried by nanoparticle can be effectively
reduced, and the applicability of the drug delivery system can be improved.
Therefore, the assessment of the toxicity of nanoparticles for transporting
drugs is an essential parameter for the construction of nanoparticle drug
delivery systems. Various methods are available for the toxicity assessment,
which can be categorized as In vitro and in vivo. Generally, In vitro methods
used to assess nanoparticle toxicity fall into two general categories:
functional assays and viability assays. Functional assays are those that seek
to assess the effects of nanoparticles on various cellular processes, whereas
viability assays are concerned solely with whether a given nanoparticle
causes death in a cell or a system of cells. The in vivo toxicity assessment is
normally performed on animal models such as mice and rats.
Bioparticles Analysis and Characterization
Figure 1. Nanoparticles types, experimental models used for the studies and
toxic effects of nanoparticles. (Vinay K., et al. International Nano Letters. 2017,
Toxicity Measurement Analysis Methods
In Vitro Assessment Assays
The functional assays tha