LOAN AND SECURITY AGREEMENT
THIS SECOND AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 23 rd day of
March, 2009, by and between Silicon Valley Bank (“Bank”) and ARCA biopharma Colorado, Inc. (f/k/a ARCA biopharma,
Inc.), a Delaware corporation (“Borrower”) whose address is 8001 Arista Place, Suite 200, Broomfield, CO 80021.
A. Bank and Borrower have entered into that certain Loan and Security Agreement dated as of July 17, 2007, as amended
by a First Amendment, dated January 23, 2009 (as the same may from time to time be further amended, modified, supplemented
or restated, the “Loan Agreement”).
B. Bank has extended credit to Borrower for the purposes permitted in the Loan Agreement.
C. Borrower has requested that Bank amend the Loan Agreement to revise the maturity date of the outstanding GC Line B
D. Bank has agreed to so amend certain provisions of the Loan Agreement, but only to the extent, in accordance with the
terms, subject to the conditions and in reliance upon the representations and warranties set forth below.
N OW , T HEREFORE , in consideration of the foregoing recitals and other good and valuable consideration, the receipt and
adequacy of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows:
1. Definitions. Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the
2. Amendment to Loan Agreement. The definition of “GC Line B Tranche Two maturity Date” in Section 13.1 of the Loan
Agreement is hereby deleted in its entirety and replaced with the following:
“ GC Line B Tranche Two Maturity Date ” is April 6, 2009.
3. Limitation of Amendment.
3.1 The amendment set forth in Section 2, above, is effective for the purposes set forth herein and shall be limited
precisely as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification