1,4-Bis-Maleimidobutane
BMB
2705
0022331
6/19/2009.
6/19/2009.
Material Safety Data Sheet
Product name
Synonym
Manufacturer
Product No.
MSDS #
Validation date
Print date
In case of emergency
Product and company identification
Responsible name
MSDS (Regulatory Affairs)
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1 .
Chemical formula
: C12H12N2O4
CHEMTREC:
800.424.9300
OUTSIDE US:
202.483.7616
Supplier
: Thermo Fisher Scientific
Pierce Biotechnology
P.O. Box 117
Rockford, IL 61105
United States
815.968.0747 or
800.874.3723
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Use of
Substance/Preparation
Refer to the instruction booklet for
proper and intended use.
Otherwise, contact supplier for
specific applications.
: Thermo Fisher Scientific
Pierce Biotechnology
P.O. Box 117
Rockford, IL 61105
United States
815.968.0747
800.874.3723
Part of Thermo Fisher Scientific
Dermal contact. Eye contact. Inhalation. Ingestion.
Emergency overview
Hazards identification
Routes of entry
Potential acute health effects
Irritating to respiratory system. Exposure to decomposition products may cause a health
hazard. Serious effects may be delayed following exposure.
Irritating to eyes.
Harmful if swallowed.
Irritating to skin.
Eyes
Skin
Inhalation
Ingestion
Physical state
Solid.
WARNING !
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. MAY BE HARMFUL
IF SWALLOWED. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL
DATA.
Harmful if swallowed. Irritating to eyes, respiratory system and skin. Do not ingest.
Avoid contact with eyes, skin and clothing. May cause target organ damage, based on
animal data. Use only with adequate ventilation. Keep container tightly closed and
sealed until ready for use. Wash thoroughly after handling.
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OSHA/HCS status
: This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
2 .
Potential chronic health effects
Chronic effects
: May cause target organ damage, based on animal data.
1/8
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Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Hazards identification
2 .
See toxicological information (section 11)
Medical conditions
aggravated by over-
exposure
Pre-existing digestive disorders and disorders involving any other target organs
mentioned in this MSDS as being at risk may be aggravated by over-exposure to this
product.
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Carcinogenicity
: No known significant effects or critical hazards.
Mutagenicity
: No known significant effects or critical hazards.
Teratogenicity
: No known significant effects or critical hazards.
Developmental effects
: No known significant effects or critical hazards.
Fertility effects
: No known significant effects or critical hazards.
Over-exposure signs/symptoms
Ingestion
: No specific data.
Skin
: Adverse symptoms may include the following:
irritation
redness
Eyes
: Adverse symptoms may include the following:
pain or irritation
watering
redness
Inhalation
: Adverse symptoms may include the following:
respiratory tract irritation
coughing
Target organs
: May cause damage to the following organs: liver.
The substance is classified as dangerous according to Directive 67/548/EEC and its amendments.
Classification
Xn; R22
Xi; R36/37/38
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Human health hazards
: Harmful if swallowed. Irritating to eyes, respiratory system and skin.
1,4-Bis-Maleimidobutane
98 - 100
Composition/information on ingredients
Name
CAS number
%
United States
3 .
There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and
in the concentrations applicable, are classified as hazardous to health or the environment and hence require
reporting in this section.
Substance/preparation
Substance
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Ingredient name
CAS
number
%
Classification
EC number
1,4-Bis-Maleimidobutane
98 - 100
Xn; R22
Xi;
R36/37/38
[1]
Europe
[1] Substance classified with a health or environmental hazard
[2] Substance with a workplace exposure limit
Occupational exposure limits, if available, are listed in section 8.
2/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Wash out mouth with water. Remove dentures if any. Move exposed person to fresh
air. Keep person warm and at rest. If material has been swallowed and the exposed
person is conscious, give small quantities of water to drink. Stop if the exposed person
feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do
so by medical personnel. If vomiting occurs, the head should be kept low so that vomit
does not enter the lungs. Get medical attention. Never give anything by mouth to an
unconscious person. If unconscious, place in recovery position and get medical
attention immediately. Maintain an open airway. Loosen tight clothing such as a collar,
tie, belt or waistband.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting
the upper and lower eyelids. Check for and remove any contact lenses. Get medical
attention.
Flush contaminated skin with plenty of water. Remove contaminated clothing and
shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing
before reuse. Clean shoes thoroughly before reuse.
Move exposed person to fresh air. If it is suspected that fumes are still present, the
rescuer should wear an appropriate mask or self-contained breathing apparatus. Keep
person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest
occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous
to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention.
If unconscious, place in recovery position and get medical attention immediately.
Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.
In case of inhalation of decomposition products in a fire, symptoms may be delayed.
The exposed person may need to be kept under medical surveillance for 48 hours.
First aid measures
Eye contact
Skin contact
Inhalation
Ingestion
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Protection of first-aiders
: No action shall be taken involving any personal risk or without suitable training. If it is
suspected that fumes are still present, the rescuer should wear an appropriate mask or
self-contained breathing apparatus. It may be dangerous to the person providing aid to
give mouth-to-mouth resuscitation.
See section 11 for more detailed information on health effects and symptoms.
Use an extinguishing agent suitable for the surrounding fire.
Fire-fighting measures
Extinguishing media
Promptly isolate the scene by removing all persons from the vicinity of the incident if
there is a fire. No action shall be taken involving any personal risk or without suitable
training.
No specific fire or explosion hazard.
Special protective
equipment for fire-fighters
Fire-fighters should wear appropriate protective equipment and self-contained breathing
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
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Special exposure hazards
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None known.
Suitable
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Not suitable
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Hazardous combustion
products
: Decomposition products may include the following materials:
carbon oxides
nitrogen oxides
Flammability of the product
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3/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
No action shall be taken involving any personal risk or without suitable training.
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilled material. Provide adequate ventilation.
Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal
protective equipment (see section 8).
Move containers from spill area. Approach release from upwind. Prevent entry into
sewers, water courses, basements or confined areas. Vacuum or sweep up material
and place in a designated, labeled waste container. Dispose of via a licensed waste
disposal contractor. Note: see section 1 for emergency contact information and section
13 for waste disposal.
Environmental precautions
Accidental release measures
: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
Personal precautions
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Large spill
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Move containers from spill area. Vacuum or sweep up material and place in a
designated, labeled waste container. Dispose of via a licensed waste disposal
contractor.
Small spill
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Store between the following temperatures: 2 to 8°C (35.6 to 46.4°F). Store in
accordance with local regulations. Store in original container protected from direct
sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see
section 10) and food and drink. Keep container tightly closed and sealed until ready for
use. Containers that have been opened must be carefully resealed and kept upright to
prevent leakage. Do not store in unlabeled containers. Use appropriate containment to
avoid environmental contamination.
Put on appropriate personal protective equipment (see section 8). Eating, drinking and
smoking should be prohibited in areas where this material is handled, stored and
processed. Workers should wash hands and face before eating, drinking and smoking.
Do not ingest. Avoid contact with eyes, skin and clothing. Use only with adequate
ventilation. Wear appropriate respirator when ventilation is inadequate. Keep in the
original container or an approved alternative made from a compatible material, kept
tightly closed when not in use. Empty containers retain product residue and can be
hazardous. Do not reuse container.
Handling and storage
Handling
Storage
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Exposure controls/personal protection
Consult local authorities for acceptable exposure limits.
8 .
Engineering measures
: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor
or mist, use process enclosures, local exhaust ventilation or other engineering controls
to keep worker exposure to airborne contaminants below any recommended or statutory
limits.
Recommended monitoring
procedures
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If this product contains ingredients with exposure limits, personal, workplace atmosphere
or biological monitoring may be required to determine the effectiveness of the ventilation
or other control measures and/or the necessity to use respiratory protective equipment.
Europe
No exposure limit value known.
4/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Exposure controls/personal protection
8 .
Use a properly fitted, air-purifying or air-fed respirator complying with an approved
standard if a risk assessment indicates this is necessary. Respirator selection must be
based on known or anticipated exposure levels, the hazards of the product and the safe
working limits of the selected respirator.
Safety eyewear complying with an approved standard should be used when a risk
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts.
Personal protective equipment for the body should be selected based on the task being
performed and the risks involved and should be approved by a specialist before handling
this product.
Personal protection
Eyes
Skin
Respiratory
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Chemical-resistant, impervious gloves complying with an approved standard should be
worn at all times when handling chemical products if a risk assessment indicates this is
necessary.
Hands
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Hygiene measures
: Wash hands, forearms and face thoroughly after handling chemical products, before
eating, smoking and using the lavatory and at the end of the working period. Appropriate
techniques should be used to remove potentially contaminated clothing. Wash
contaminated clothing before reusing. Ensure that eyewash stations and safety showers
are close to the workstation location.
Environmental exposure
controls
: Emissions from ventilation or work process equipment should be checked to ensure they
comply with the requirements of environmental protection legislation. In some cases,
fume scrubbers, filters or engineering modifications to the process equipment will be
necessary to reduce emissions to acceptable levels.
Decomposes.
Solid.
191 to 202°C (375.8 to 395.6°F)
Soluble in the following materials: methanol.
248.24 g/mole
White. Off-white.
Boiling/condensation point
Melting/freezing point
Physical and chemical properties
Physical state
Molecular weight
Solubility
Color
C12H12N2O4
Molecular formula
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The product is stable. Under normal conditions of storage and use, hazardous
polymerization will not occur.
No specific data.
Will not occur.
Under normal conditions of storage and use, hazardous decomposition products should
not be produced.
No specific data.
Stability and reactivity
Chemical stability
Conditions to avoid
Incompatible materials
Hazardous decomposition
products
Possibility of hazardous
reactions
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5/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Toxicological information
United States
11 .
Acute toxicity
Conclusion/Summary
: To the best of our knowledge, the toxicological properties of this substance have not
been thoroughly investigated.
Chronic toxicity
Conclusion/Summary
: Not available.
Carcinogenicity
Conclusion/Summary
: Not available.
Mutagenicity
Conclusion/Summary
: Not available.
Teratogenicity
Conclusion/Summary
: Not available.
Reproductive toxicity
No known significant effects or critical hazards.
Chronic effects
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No known significant effects or critical hazards.
Carcinogenicity
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No known significant effects or critical hazards.
Mutagenicity
No known significant effects or critical hazards.
Teratogenicity
Developmental effects
: No known significant effects or critical hazards.
Fertility effects
: No known significant effects or critical hazards.
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Europe
Not available.
Conclusion/Summary
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Ecological information
United States
Environmental effects
: No known significant effects or critical hazards.
12 .
Aquatic ecotoxicity
Conclusion/Summary
: Not available.
Other adverse effects
: No known significant effects or critical hazards.
The generation of waste should be avoided or minimized wherever possible. Dispose of
surplus and non-recyclable products via a licensed waste disposal contractor. Disposal
of this product, solutions and any by-products should at all times comply with the
requirements of environmental protection and waste disposal legislation and any regional
local authority requirements. Avoid dispersal of spilled material and runoff and contact
with soil, waterways, drains and sewers.
Waste disposal
Disposal considerations
Disposal should be in accordance with applicable regional, national and local laws and regulations.
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Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
Hazardous waste
: The classification of the product may meet the criteria for a hazardous waste.
6/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Transport information
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DOT Classification
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Not available.
Not available.
IATA-DGR Class
Not available.
Regulatory
information
UN number
Proper shipping
name
Classes
PG*
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Not
regulated.
14 .
PG* : Packing group
Irritating material
Target organ effects
HCS Classification
Regulatory information
U.S. Federal regulations
United States inventory (TSCA 8b): Not determined.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean Air Act (CAA) 112 accidental release prevention: No products were found.
Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
CEPA Toxic substances: This material is not listed.
Canadian ARET: This material is not listed.
Canadian NPRI: This material is not listed.
Alberta Designated Substances: This material is not listed.
Ontario Designated Substances: This material is not listed.
Quebec Designated Substances: This material is not listed.
WHMIS (Canada)
Class D-2B: Material causing other toxic effects (Toxic).
International regulations
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No
products were found.
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Canada
United States
EU regulations
15 .
Canadian lists
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Canada inventory
: Canada inventory: Not determined.
R22- Harmful if swallowed.
R36/37/38- Irritating to eyes, respiratory system and skin.
Hazard symbol or symbols
Risk phrases
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Harmful
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7/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax
1,4-Bis-Maleimidobutane
Regulatory information
15 .
Australia inventory (AICS): Not determined.
China inventory (IECSC): Not determined.
Korea inventory (KECI): Not determined.
Philippines inventory (PICCS): Not determined.
Japan inventory (ENCS): Not determined.
International lists
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Other information
Hazardous Material
Information System (U.S.A.)
2
0
0
0
0
2
National Fire Protection
Association (U.S.A.)
Health
Special
Instability
Flammability
Health
Flammability
Physical hazards
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. MAY BE HARMFUL
IF SWALLOWED. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL
DATA.
Label requirements
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Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
Date of printing
Date of issue
Date of previous issue
Version
6/19/2009.
6/19/2009.
1
No previous validation.
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16 .
The customer is responsible for determining the PPE code for this material.
Indicates information that has changed from previously issued version.
Full text of R-phrases
referred to in sections 2 and
3 - Europe
: R22- Harmful if swallowed.
R36/37/38- Irritating to eyes, respiratory system and skin.
Full text of classifications
referred to in sections 2 and
3 - Europe
: Xn - Harmful
Xi - Irritant
This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
8/8
6/19/2009.
Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce
Pierce PO Box 117 61105 (815) 968-7316 Fax