GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF
DISSEMINATED INTRAVASCULAR COAGULATION
British Committee for Standards in Haematology
Address for correspondence:
British Society for Haematology
100 White Lion Street
1Department of Medicine, Academic Medical Center, Amsterdam, Netherlands
2Department of Haematology, University of Liverpool, England, UK
3Department of Haematology, Aberdeen Royal Infirmary, Scotland, UK
While the advice and information in these guidelines is believed to be true and
accurate at the time of going to press, neither the authors, the British Society for
Haematology nor the publishers accept any legal responsibility for the content of
Date for guideline review October 2010
The diagnosis of DIC should encompass both clinical and laboratory
information. (Grade C, Level IV.)
The ISTH DIC scoring system provides objective measurement of DIC.
Where DIC is present the scoring system correlates with key clinical
observations and outcomes. (Grade C, Level IV)
It is important to repeat the tests to monitor the dynamically changing
scenario based on laboratory results and clinical observations. (Grade B,
The cornerstone of the treatment of DIC is treatment of the underlying
condition. (Grade C, Level IV)
Transfusion of platelets or plasma (components) in patients with DIC
should not primarily be based on laboratory results and should in general
be reserved for patients who present with bleeding. (Grade C, Level IV).
In patients with DIC and bleeding or at high risk of bleeding (e.g.
postoperative patients or patients due to undergo an invasive procedure)
and a platelet count of <50x109/l transfusion of platelets should be
considered (Grade C, Level IV).
In non-bleeding patients with DIC, prophylactic platelet transfusion is not
given unless it is perceived that there