Rhodamine Phalloidin 7462 1860257 1860258 1891933 2/1/2008. 2/1/2008. Material Safety Data Sheet Product name Manufacturer Product No. MSDS # Validation date Print date In case of emergency Product and company identification Responsible name MSDS (Regulatory Affairs) Rhodamine Phalloidin : : : : : : : 1 . CHEMTREC: 800.424.9300 OUTSIDE US: 202.483.7616 Supplier : ThermoFisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 Use of Substance/Preparation Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. : ThermoFisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 800.874.3723 Dermal contact. Eye contact. Inhalation. Ingestion. Emergency overview Hazards identification Routes of entry Potential acute health effects Harmful by inhalation. No known significant effects or critical hazards. Harmful if swallowed. Toxic in contact with skin. Eyes Skin Inhalation Ingestion Physical state Solid. TOXIC IN CONTACT WITH SKIN. HARMFUL IF SWALLOWED. HARMFUL BY INHALATION. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA. May cause target organ damage, based on animal data. : : : : : : : OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). 2 . Potential chronic health effects Carcinogenicity : No known significant effects or critical hazards. Mutagenicity : No known significant effects or critical hazards. Teratogenicity : No known significant effects or critical hazards. Developmental effects : No known significant effects or critical hazards. Chronic effects : May cause target organ damage, based on animal data. Fertility effects : No known significant effects or critical hazards. Over-exposure signs/symptoms Ingestion : No specific data. Skin : No specific data. Inhalation : No specific data. Target organs : May cause damage to the following organs: blood, kidneys, liver, upper respiratory tract, central nervous system (CNS). 1/7 2/1/2008. Rhodamine Phalloidin Hazards identification 2 . See toxicological information (section 11) Medical conditions aggravated by over- exposure Pre-existing disorders involving any target organs mentioned in this MSDS as being at risk may be aggravated by over-exposure to this product. : Eyes : No specific data. The substance is not classified as dangerous according to Directive 67/548/EEC and its amendments. Classification Not classified. : Rhodamine Phalloidin 219920-04-4 98 - 100 Composition/information on ingredients Name CAS number % United States 3 . There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Substance/preparation Substance : Wash out mouth with water. Remove dentures if any. Move exposed person to fresh air. Keep person warm and at rest. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to- mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. First aid measures Eye contact Skin contact Inhalation Ingestion : : : : 4 . Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. See section 11 for more detailed information on health effects and symptoms. Use an extinguishing agent suitable for the surrounding fire. Fire-fighting measures Extinguishing media No specific fire or explosion hazard. 5 . None known. Suitable : Not suitable : Flammability of the product : 2/7 2/1/2008. Rhodamine Phalloidin Fire-fighting measures 5 . Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Special protective equipment for fire-fighters Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. : Special exposure hazards : Hazardous combustion products : No specific data. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment (see section 8). Move containers from spill area. Approach release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Vacuum or sweep up material and place in a designated, labeled waste container. Dispose of via a licensed waste disposal contractor. Note: see section 1 for emergency contact information and section 13 for waste disposal. Environmental precautions Accidental release measures : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Personal precautions : Large spill : 6 . Move containers from spill area. Vacuum or sweep up material and place in a designated, labeled waste container. Dispose of via a licensed waste disposal contractor. Small spill : Do not store above the following temperature: -20°C (-4°F). Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Put on appropriate personal protective equipment (see section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Do not ingest. Avoid contact with eyes, skin and clothing. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Handling and storage Handling Storage : : 7 . Exposure controls/personal protection Consult local authorities for acceptable exposure limits. 8 . Recommended monitoring procedures : If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Europe No exposure limit value known. 3/7 2/1/2008. Rhodamine Phalloidin Exposure controls/personal protection 8 . Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Personal protection Eyes Skin Respiratory : : : Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Hands : Other protection : Handle the material in a fume hood/cupboard or under local exhaust ventilation. Engineering measures : No special ventilation requirements. Good general ventilation should be sufficient to control worker exposure to airborne contaminants. If this product contains ingredients with exposure limits, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure below any recommended or statutory limits. Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Environmental exposure controls : Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. Solid. Partially soluble in the following materials: cold water and hot water. 1250 g/mole Physical and chemical properties Physical state Molecular weight Solubility : : : 9 . The product is stable. Under normal conditions of storage and use, hazardous polymerization will not occur. No specific data. Will not occur. Under normal conditions of storage and use, hazardous decomposition products should not be produced. No specific data. Stability and reactivity Stability Conditions to avoid Materials to avoid Hazardous decomposition products Hazardous polymerization : : : : : 10 . 4/7 2/1/2008. Rhodamine Phalloidin Toxicological information United States 11 . Acute toxicity Rhodamine Phalloidin LD50 Intraperitoneal Mouse 2 mg/kg - Product/ingredient name Result Species Dose Exposure Conclusion/Summary : Results above are those of Phalloidin. Chronic toxicity Conclusion/Summary : Not available. Carcinogenicity Conclusion/Summary : Not available. Mutagenicity Conclusion/Summary : Not available. Teratogenicity Conclusion/Summary : Not available. Reproductive toxicity Conclusion/Summary : Not available. Classification Rhodamine Phalloidin - - - - - None. Product/ingredient name ACGIH EPA NIOSH NTP IARC OSHA No known significant effects or critical hazards. Chronic effects : No known significant effects or critical hazards. Carcinogenicity : No known significant effects or critical hazards. Mutagenicity No known significant effects or critical hazards. Teratogenicity Developmental effects : No known significant effects or critical hazards. Fertility effects : No known significant effects or critical hazards. : : Europe Ecological information United States Environmental effects : No known significant effects or critical hazards. 12 . Aquatic ecotoxicity Conclusion/Summary : Not available. Other adverse effects : No known significant effects or critical hazards. The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Waste disposal Disposal considerations Disposal should be in accordance with applicable regional, national and local laws and regulations. : 13 . Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Hazardous waste : Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. 5/7 2/1/2008. Rhodamine Phalloidin Transport information 6.1 DOT Classification Toxic solid, organic, n.o.s. (rhodamine phalloidin) II Toxic solid, organic, n.o.s. (phalloidin compound) (Rhodamine Phalloidin) 2811 IATA-DGR Class 6.1 Regulatory information UN number Proper shipping name Classes PG* II 2811 14 . PG* : Packing group Target organ effects HCS Classification Regulatory information U.S. Federal regulations United States inventory (TSCA 8b): This material is not listed. Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean Air Act (CAA) 112 accidental release prevention: No products were found. Clean Air Act (CAA) 112 regulated flammable substances: No products were found. Clean Air Act (CAA) 112 regulated toxic substances: No products were found. CEPA Toxic substances: This material is not listed. Canadian ARET: This material is not listed. Canadian NPRI: This material is not listed. Alberta Designated Substances: This material is not listed. Ontario Designated Substances: This material is not listed. Quebec Designated Substances: This material is not listed. Australia inventory (AICS): Not determined. China inventory (IECSC): Not determined. Korea inventory (KECI): Not determined. Philippines inventory (PICCS): Not determined. Japan inventory (ENCS): Not determined. WHMIS (Canada) Class D-1A: Material causing immediate and serious toxic effects (Very toxic). International regulations International lists SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found. : : : : Canada United States EU regulations 15 . Canadian lists : United States inventory (TSCA 8b) : United States inventory (TSCA 8b): This material is not listed. Canada inventory : Canada inventory: Not determined. This product is not classified according to EU legislation. Risk phrases : : 6/7 2/1/2008. Rhodamine Phalloidin Other information Hazardous Material Information System (U.S.A.) 2 0 0 0 0 2 National Fire Protection Association (U.S.A.) Health Special Instability Flammability Health Flammability Physical hazards TOXIC IN CONTACT WITH SKIN. HARMFUL IF SWALLOWED. HARMFUL BY INHALATION. MAY CAUSE TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA. Label requirements : Notice to reader To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. Date of printing Date of issue Date of previous issue Version 2/1/2008. 2/1/2008. 1 No previous validation. : : : : : : 16 . The customer is responsible for determining the PPE code for this material. Indicates information that has changed from previously issued version. 7/7 2/1/2008.