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WCVD 6 – Examples of 250-word abstract for Free Communications and Posters FREE COMMUNICATION: EXAMPLE (250-word abstract) Adult-onset hair loss in Chesapeake Bay retrievers: a clinical and histological study R. CERUNDOLO, E. MAULDIN, M. GOLDSCHMIDT, S. LOMBARDINI, K. REFSAL, J. OLIVER School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA; College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA Hair loss in Chesapeake Bay retrievers has been increasingly recognized by breeders in recent years. Anecdotal reports suggest an endocrine disorder or follicular dysplasia as the underlying cause, but no scientific study has been done to investigate the underlying problem. A prospective study was carried out in collaboration with the American Chesapeake Club. Affected dogs were recruited into the study. Routine dermatological and hormonal (blood and urine) tests, and skin biopsies were performed. Ten dogs (age 1.5-10 years), seven females (two spayed) and three males (two neutered), were included in the study. All dogs had mild or severe hair loss affecting the lateral ventral chest, flanks, rump and thighs. Affected dogs were clinically healthy. Testing 10 consecutive morning samples revealed normal thyroid hormone panels, insulin-like growth factor-1 levels, and urinary cortisol:creatinine ratios. In 6 of 10 dogs, an adrenal hormone panel showed slight or moderate increased values pre- and/or post-ACTH stimulation of cortisol (3/6), 17-hydroxyprogesterone (5/6), androstenedione (3/6), estradiol (2/6) and progesterone (6/6). The major histopathologic changes resembled canine flank alopecia and follicular dysplasia with pronounced infundibular hyperkeratosis, mild follicular atrophy, and occasional melanin clumping with dystrophic hair shafts. Chesapeake Bay retrievers suffer from a type of hair loss that is likely related to an abnormal production of adrenal sex hormone. Further studies are currently underway to determine if there is a heritable basis for this disease and to evaluate therapeutic options. Funding: University of Pennsylvania WCVD 6 – Examples of 250-word abstract for Free Communications and Posters FREE COMMUNICATION: EXAMPLE (250-word abstract) Pemphigus foliaceus in 97 dogs R.S. MUELLER, I. KREBS, H.T. POWER, K.V. FIESELER College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA; Dermatology for Animals, Campbell, California, USA Medical records of 97 dogs with pemphigus foliaceus were evaluated. The average age of onset was 6.3 years (range 0.5-16 years). Crusts were the most common lesions in 79 dogs; pustules were observed in 36 dogs. No gender predisposition was identified. The trunk was the most commonly involved area (51 dogs), followed by the inner pinnae (46), dorsal muzzle (37), footpads (32), periocular area (26), outer pinnae (23) and planum nasale (23). Facial involvement only was noted in 15 dogs. Of the 48 dogs in which cytology was recorded, concurrent infections were identified in 32 dogs, acantholytic cells were seen in 37 dogs, numerous neutrophils in 35 dogs, and numerous eosinophils in 8 cases. Final control of the disease was achieved with: glucocorticoids (24 dogs); azathioprine (9); chlorambucil (1); aurothioglucose (1); a combination of glucocorticoids and azathioprine (31); glucocorticoids and aurothioglucose (2); tetracycline/doxycycline and niacinamide (8); prednisolone, tetracycline and niacinamide (1); fatty acid supplementation (2); and tacrolimus (1). One dog was completely tapered off drugs and stayed in remission. Average time to improvement was 6 weeks, and average time to remission was 9.3 months. Forty-three dogs were followed for less than 12 months, and 12 of these were euthanized: eight for other diseases and four due to a lack of response or adverse effects of treatment. In 54 dogs, the follow up was greater than 12 months; four of these dogs were euthanized (one due to an unrelated cause, one due to neoplastic disease and two related to pemphigus foliaceus). Funding: Self-funded WCVD 6 – Examples of 250-word abstract for Free Communications and Posters POSTER: EXAMPLE (250-word abstract) Black hair follicular dysplasia in a dog: an ultrastructural study using transmission electron microscopy A. SHIMIZU, A. ISHIKO, N. MURAYAMA, M. NAGATA School of Medicine, Keio University, Tokyo, Japan; Memuro Animal Clinic, Hokkaido, Japan; Animal Dermatology Center, ASC, Tokyo, Japan Black hair follicular dysplasia (BHFD) is a rare disorder in which dogs with bicolor or tricolor coats lose hair only in the black areas at an early age. Large melanin granule deposits within the hair shafts and follicles are the hallmark of this disorder, but the pathogenesis remains uncertain. A study using a scanning electron microscopy has suggested that an abnormality of pigment transfer may play a role in the pathogenesis. Here, we present a BHFD dog, in which the lesions were examined by transmission electron microscopy. A three-year-old male mixed-breed dog with black-and-white hair coat presented with a 2- year history of alopecia in the black-haired areas. Physical examination revealed no abnormalities other than alopecia. Skin scrapings, fungal culture, CBC, serum chemistry analysis, and endocrine tests were unremarkable. Histopathologically, no abnormality was observed in the white-haired areas, whereas black- haired areas showed numerous large melanin granules in hair shafts and follicles. Based on these findings, the dog was diagnosed as having BHFD. Transmission electron microscopy revealed numerous melanin clumps consisting of atypical (both in shape and size) melanosomes in the lower part of telogen hair follicles. Some melanin clumps were surrounded by cell membrane-like structure, in which degenerative nuclei were recognized. It is speculated that melanin clumps originate from melanin blockade. Further investigation is needed for a better understanding of the pathogenesis of BHFD. Funding: Self-funded
