HEP is an award-winning print and online brand for people living with and affected by viral hepatitis. Offering unparalleled editorial excellence since 2010, HEP and HEPmag.com are the go-to source for educational and social support for people living with hepatitis.At Smart + Strong, HEP's parent, we know that when you are armed with expert, unbiased health care information; when you are empowered and inspired to advocate for your needs; and when you can connect to others dealing with a similar health condition, you are more likely to survive-and thrive.Smart + Strong's health-focused magazines and websites bring together large, diverse populations to share lifesaving information with them and to serve as platforms for you to tell health care providers, insurance companies, the media, our government and especially each other what it's like to live with—and overcome—a given health challenge.We also publish POZ magazine, POZ.com, Real Health magazine and RealHealthMag.com.Contact InformationHEP MagazineSmart + Strong212 West 35th Street, 8th FloorNew York, New York 10001-2508General Phone 212-242-2163General Fax 212-675-8505https://www.hepmag.com/
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Hepatitis C Treatment
The goal of treatment for hepatitis C virus (HCV) is to cure the virus, which can be done with a combination of drugs. The specific meds
used and the duration of treatment depend on a number of factors, including HCV genotype (genetic structure of the virus),
viral load, past treatment experience, degree of liver damage, ability to tolerate the prescribed treatment, and whether the person is
waiting for a liver transplant or is a transplant recipient. In some cases, HCV treatment may be limited by your health insurance plan or
drug formulary.
Here’s information about each type, or class, of approved HCV treatment along with drugs in the late stages of development:
Multi-Class Combination Drugs
Brand Name
Generic Name
Status
Pharmaceutical Company
Epclusa*
sofosbuvir + velpatasvir
Approved
Gilead Sciences
Harvoni*
ledipasvir + sofosbuvir
Approved
Gilead Sciences
Mavyret
glecaprevir + pibrentasvir
Approved
AbbVie
Vosevi
sofosbuvir/velpatasvir/
voxilaprevir
Approved
Gilead Sciences
Zepatier
elbasvir + grazoprevir
Approved
Merck
n/a
daclatasvir + asunaprevir +
beclabuvir
Phase III
Bristol-Myers Squibb
*generic available
What are they?
Multi-class combination drugs are a combination of drugs formulated into a single pill or package of pills. For instance, the drug Harvoni
combines two drugs, ledipasvir and sofosbuvir. Ledipasvir is an NS5A inhibitor and is only sold as part of Harvoni; sofosbuvir may be
prescribed separately under the brand name of Sovaldi.
Pegylated Interferon Alfa
Brand Name
Generic Name
Status
Pharmaceutical Company
Pegasys
peginterferon alfa-2a
Approved
Genentech
What are they?
Interferon is a protein made by the immune system, named because it interferes with viral reproduction. In addition, interferon signals
the immune system to recognize and respond to microorganisms, including viral and bacterial infections. Infected cells release inter-
feron to trigger the immune response. There are three types of interferon: alfa, beta and gamma. Interferon alfa is