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Schering-Plough Animal Health Corporation 
556 Morris Avenue 
Summit, NJ  07901
  
MATERIAL SAFETY DATA SHEET 
  
Schering-Plough urges each user or recipient of this MSDS to read the entire data sheet to become aware of the hazards associated with this material.
  
 
SECTION 1.  IDENTIFICATION OF SUBSTANCE AND CONTACT INFORMATION
  
MSDS NAME:
SYNERGIZED DELICE Pour-On Insecticide 
  
SYNONYM(S):
AGRILAB BACK SIDE PLUS 
ASPEN ECTO ZAP PLUS 
ATROBAN DELICE PLUS Insecticide 
DURVET ECTIBAN SYNERGIZED DELICE 
SYNERGIZED EXPAR Pour-On 
SYNERGIZED DELICE Pour-On For Cattle, Sheep, and Their Premises
  
MSDS NUMBER:
SP000915
  
EMERGENCY NUMBER(S):
Schering-Plough Security Control Center  (908) 820-6921 (24 hours) 
Transportation Emergencies -  CHEMTREC: 
(800) 424-9300 (Inside Continental USA)   
(703) 527-3887 (Outside Continental USA) 
Rocky Mountain Poison Center (For Human Exposure): 
(303) 595-4869 
Animal Health Technical Services: 
For Animal Adverse Events: Small Animals and Horses: (800) 224-5318  
For Animal Adverse Events: Livestock: (800) 211-3573   
For Animal Adverse Events: Poultry: (800) 219-9286
  
INFORMATION:
Animal Health Technical Services:  
For Small Animals and Horses: (800) 224-5318  
For Livestock: (800) 211-3573  
For Poultry: (800) 219-9286 
  
SCHERING-PLOUGH MSDS HELPLINE:
(800) 770-8878 (US and Canada) 
(908) 629-3657 (Worldwide) 
Monday to Friday, 9am to 5pm (US Eastern Time) 
  
The trademarks indicated by CAPITAL LETTERS in this [M]SDS are the property of, licensed to, promoted or distributed by Schering-Plough 
Corporation, its subsidiaries or related companies.
 
SECTION 2.  HAZARDS IDENTIFICATION
 
 
  
EMERGENCY OVERVIEW 
 
Liquid
SYNERGIZED DELICE Pour-On Insecticide 
 
 
Odorless
MSDS NUMBER: SP000915
Latest Revision Date: 18-Nov-2005
 
Clear, Amber
Page 1 of 7 
Published Date:  18-Nov-2005
 
Absorbed through the skin.
May be irritating to respiratory system.
May be an aspiration hazard if ingested.
May be harmful by inhalation.
May cause allergic reactions in susceptible individuals.
 
 
POTENTIAL HEALTH EFFECTS:
 
This product is a permethrin insecticide and contains petroleum distallates.  This product may cause mild skin sensitization in susceptible individuals or 
may cause slight eye irritation.  
The U.S. Environmental Protection Agency's (EPA) labeling criteria indicate that this product is harmful if absorbed through skin. 
This product contains permethrin, a synthetic Type I pyrethroid ester.   Occupational exposure to permethrin has induced temporary skin and facial 
sensations (feelings of numbness and tingling).  Workers exposed to permethrin have also reported irritative symptoms, such as itching and burning of 
the skin, itching and irritation of the eyes, and irritation of the upper respiratory tract as well as increased nasal secretions.   Anaphylactic reactions 
including bronchospasm and shock may occur in very sensitive individuals.  Ingestion of large amounts may cause central nervous system effects 
resulting in seizures, coma, and respiratory arrest. 
Ingestion of pyrethroid esters has caused stomach pain, nausea and vomiting, headache, dizziness, numbness and tingling, anorexia, fatigue, tremors, 
and intermittent convulsions. 
Piperonyl butoxide is used to enhance the action of pyrethrin and pyrethroid insecticides.  Clinical effects from piperonyl butoxide exposure include 
nausea, vomitting, diarrhea, loss of appetite, and mild central nervous system depression.  It has been reported to cause decreases in the number of red 
blood cells, white blood cells and platelets in the circulating blood.  
Petroleum distillates may be skin, eye, and respiratory tract irritants.  Repeated skin contact may cause oil acne or dermatitis.  Exposure to large 
amounts of petroleum distillates by inhalation or ingestion may cause CNS depression or excitement, headaches, drowsiness, nausea, vomiting, 
diarrhea, laxative effects, lung damage, or an irregular heartbeat.  Aspiration of liquid into the lungs may produce chemical pneumonitis.
 
 
LISTED CARCINOGENS
CHEMICAL NAME
CAS NUMBER
OSHA
IARC
NTP
ACGIH
Permethrin Technical
52645-53-1
Listed.
Piperonyl Butoxide
51-03-6
Listed.
 
Permethrin technical is classified by IARC as a Group 3 carcinogen  (unclassifiable as to carcinogenicity in humans). Piperonyl Butoxide is classified by 
IARC as a Group 3 carcinogen (unclassifiable as to carcinogenicity in humans).
  
SECTION 3.  COMPOSITION AND INFORMATION ON INGREDIENTS
  
PRODUCT USE:
Veterinary product
 
CHEMICAL FORMULA:
Mixture.
 
The formulation for this product is proprietary information.  Only hazardous ingredients in concentrations of 1% or greater and/or carcinogenic ingredients 
in concentrations of 0.1% or greater are listed in the Chemical Composition table.  Active ingredients in any concentration are listed.  For additional 
information about carcinogenic ingredients see Section 3.
 
  
CHEMICAL COMPOSITION
CHEMICAL NAME
CAS NUMBER
PERCENT
Permethrin Technical
52645-53-1
1
Piperonyl Butoxide
51-03-6
1
Distillates, petroleum, solvent-refined light paraffinic
64741-89-5
40-80
Distillates, petroleum, solvent-refined heavy paraffinic
64741-88-4
20-50
 
  
ADDITIONAL INFORMATION: 
This MSDS is written to provide health and safety information for individuals who will be handling the final 
product formulation during research, manufacturing, and distribution.  For health and safety information for 
individual ingredients used during manufacturing, refer to the appropriate MSDS for each ingredient.  Refer 
to the package insert or product label for handling guidance for the consumer.  
  
  
SYNERGIZED DELICE Pour-On Insecticide 
 
MSDS NUMBER: SP000915
May cause effects to:
- central nervous system
- gastrointestinal tract
- respiratory system
- cardiovascular system
- fetus
Latest Revision Date: 18-Nov-2005
 
Very toxic to aquatic organisms.
Page 2 of 7 
Published Date:  18-Nov-2005
 
SECTION 4. FIRST AID MEASURES
  
INHALATION:
Remove to fresh air.  If any trouble breathing, get immediate medical attention.  Administer artificial 
respiration if breathing has ceased.  If irritation or symptoms occur or persist, consult a physician.
  
SKIN CONTACT:
In case of skin contact, IMMEDIATELY flush exposed skin thoroughly with plenty of water.  While wearing 
protective gloves, remove any contaminated clothing, including shoes and continue to wash skin 
thoroughly with soap and water for at least 15 minutes. Get IMMEDIATE medical attention.  Treat 
symptomatically.
  
EYE CONTACT:
In case of eye contact, immediately rinse eyes thoroughly with plenty of water.  If wearing contact lenses, 
remove only after initial rinse, and continue rinsing eyes for at least 15 minutes.  If irritation occurs or 
persists, consult a physician.
  
INGESTION:
DO NOT induce vomiting or give any liquid to drink.  IMMEDIATELY consult a physician for treatment 
advice.
  
NOTE TO PHYSICIAN:
This product is a permethrin insecticide and contains petroleum distallates.  Vomiting is contraindicated 
due to the possibility of aspiration pneumonia. 
  
SECTION 5. FIRE FIGHTING MEASURES
  
FLAMMABILITY DATA: 
 
 
Flash Point: 
93.3 deg C ( > 200 deg F )    Method: Tagliabue closed cup (TCC)
 
  
  
  
SPECIAL FIRE FIGHTING PROCEDURES:
Wear full protective clothing and self-contained breathing apparatus (SCBA).
  
SUITABLE EXTINGUISHING MEDIA:
Water spray. Dry chemical. Foam.
  
See Section 9 for Physical and Chemical Properties. 
 
SECTION 6. ACCIDENTAL RELEASE MEASURES
  
PERSONAL PRECAUTIONS:
Keep personnel away from the clean-up area. Wear appropriate personal protective equipment as specified in Section 8.
 
SPILL RESPONSE / CLEANUP:
All spills should be handled according to site requirements and based on precautions cited in the MSDS.  In the case of liquids, use proper absorbent 
materials. For laboratories and small-scale operations, incidental spills within a hood or enclosure should be cleaned by using a HEPA filtered vacuum or 
wet cleaning methods as appropriate.  For large dry or liquid spills or those spills outside enclosure or hood, appropriate emergency response personnel 
should be notified. In manufacturing and large-scale operations, HEPA vacuuming prior to wet mopping or cleaning is required.
 
ENVIRONMENTAL PRECAUTIONS:
This product is very toxic to aquatic organisms. Do not allow product to reach ground water, water course, sewage or drainage systems.
 
 
See Sections 9 and 10 for additional physical, chemical, and hazard information.  
 
SECTION 7. HANDLING AND STORAGE
  
HANDLING:
Avoid contact with eyes. Avoid contact with skin and clothing. Keep containers adequately sealed during material transfer, transport, or when not in use. 
Appropriate handling of this material is dependent on many factors, including physical form, duration and frequency of process or task, and effectiveness 
of engineering controls.  Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all exposure control 
measures.  See Section 8 (Exposure Controls) for additional guidance.
 
STORAGE:
Store in a cool, dry, well ventilated area. Do not store near heat or open flame.
 
 
See Section 8 for exposure controls and additional safe handling information.  
 
SECTION 8. EXPOSURE CONTROLS AND PERSONAL PROTECTION
  
  
MSDS NUMBER: SP000915
SYNERGIZED DELICE Pour-On Insecticide 
Latest Revision Date: 18-Nov-2005
 
Page 3 of 7 
Published Date:  18-Nov-2005
EXPOSURE CONTROLS:
The health hazard risks of handling this material are dependent on many factors, including physical form, duration and frequency of process or task, and 
effectiveness of engineering controls.  Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all 
exposure control measures.  Exposure controls for normal operating or routine procedures follow a tiered strategy.  Engineering controls are the 
preferred means of long-term or permanent exposure control.  If engineering controls are not feasible, appropriate use of personal protective equipment 
(PPE) may be considered as alternative control measures.  However, PPE should not be used as a method of permanent or long-term exposure control.  
Exposure controls for non-routine operations must be evaluated and addressed as part of the site-specific risk assessment.
 
 
RECOMMENDED PERSONAL PROTECTIVE EQUIPMENT (PPE): 
  
 
Respiratory Protection:
Respiratory protective equipment (RPE) may be required for certain laboratory and large-scale 
manufacturing tasks if potential airborne breathing zone concentrations of substances exceed the relevant 
exposure limit(s).  Workplace risk assessment should be completed before specifying and implementing 
RPE usage.  Potential exposure points and pathways, task duration and frequency, potential employee 
contact with the substance, and the ability of the substance to be rendered airborne during specific tasks 
should be evaluated.  Initial and ongoing strategies of quantitative exposure measurement should be 
obtained as required by the workplace risk assessment.  All RPE must conform to local and regional 
specifications for efficacy and performance.  Consult your site or corporate health and safety professional 
for additional guidance.
 
 
Skin Protection:
Gloves that provide an appropriate barrier to the skin are recommended if there is potential for contact with 
this material.  Consult your site safety staff for guidance.
 
 
Eye Protection:
Safety glasses with side shields.  Use of goggles or full face protection may be required based on hazard, 
potential for contact, or level of exposure.  Consult your site safety staff for guidance.
 
 
Body Protection:
In small-scale or laboratory operations, lab coats or equivalent protection is required.  Disposable Tyvek or 
other dust impermeable suit should be considered based on procedure or level of exposure.  Use of 
additional PPE such as shoe coverings, gauntlets, hood, or head covering may be necessary.  Consult 
your site safety staff for guidance. 
In large-scale or manufacturing operations, disposable Tyvek or other dust impermeable suit is 
recommended and based on level of exposure.  Use of additional PPE such as shoe coverings, gauntlets, 
hood, or head covering may be necessary.  Consult your site safety staff for guidance.
 
EXPOSURE LIMIT VALUES
 
No exposure limits are available for the active ingredient(s) or any other hazardous ingredient in this formulation.
  
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
  
FORM:
Liquid
COLOR: 
Clear, Amber
ODOR: 
Odorless
VAPOR PRESSURE: 
< 2  mmHg @ 25 deg C 
SPECIFIC GRAVITY: 
0.840 to 0.890 at  20 deg C 
SOLUBILITY: 
 
Water:
Negligible
 
Kerosene, diesel fuel, and xylene:        Miscible
 
ADDITIONAL INFORMATION: 
Viscosity:  25 to 40 cps 
 
  
See Section 5 for flammability/explosivity information.  
 
SECTION 10. STABILITY AND REACTIVITY
  
STABILITY/ REACTIVITY:
Stable under normal conditions.
 
INCOMPATIBLE MATERIALS / CONDITIONS TO AVOID:
Open flames and high temperatures. Oxidizers.
 
HAZARDOUS DECOMPOSITION PRODUCTS / REACTIONS:
Carbon oxides (COx). Organic vapors. Chlorine.
  
SECTION 11. TOXICOLOGICAL INFORMATION
  
The information presented below is for the formulation or from studies using similar formulas containing the same active and/or hazardous ingredients 
found in this product.
 
  
MSDS NUMBER: SP000915
SYNERGIZED DELICE Pour-On Insecticide 
Latest Revision Date: 18-Nov-2005
 
Page 4 of 7 
Published Date:  18-Nov-2005
ACUTE TOXICITY DATA 
  
 
  
INHALATION: 
Permethrin:  LC50 (4hr): 2.3 mg/L (rat)
 
SKIN: 
A 5% permethrin cream was absorbed percutaneously in only small amounts and metabolized rapidly in the skin and excreted in the urine.  
 
REPEAT DOSE TOXICITY DATA  
 
SUBCHRONIC / CHRONIC TOXICITY: 
In sub-chronic studies ranging from 14 days to 26 weeks, rats and mice were treated with oral dosages of permethrin up to 10,000 mg/kg.  Dose-
dependent effects such as an increase in liver/body weight ratio, hypertrophy of the liver, and clinical signs of poisoning such as tremor were observed.  
The no-observed effects-level (NOEL) in rats ranged from 20 mg/kg diet (in studies lasting 90 days or 6 months) to 1500 mg/kg diet (in a 6-month study).  
Chronic studies ranging from 1 to 2 years were conducted in rats, mice and dogs.  Dosages varied with species ranging from 1 mg/kg/day to 375 
mg/kg/day of permethrin.  Target organs of toxicity were the liver (increased liver weight and hepatocellular swelling), lung (increased weight), and testes 
(decreased weight).  Depression and increased mortality were observed in mice at 75 mg/kg/day and above.  Additional signs and symptoms of toxicity 
in the rat include hyperexcitation, sparring behavior, aggressiveness, enhanced startle response, whole body tremor and prostration. 
Piperonyl Butoxide:  Mice given 0.3 to 0.9% in their diet for 20 days had increased liver weights and other signs of liver toxicity.   Repeat dose toxicity 
studies on piperonyl butoxide were conducted in mice, rats, and dogs in studies ranging from 7 weeks to 1 year in duration, and at dosage levels ranging 
from 62.5 to 30,000 mg/kg.  Effects on body weight, food consumption, organ weights, and the liver were observed.
 
REPRODUCTIVE / DEVELOPMENTAL TOXICITY: 
In a three-generation reproductive study with permethrin, rats were administered doses ranging from 25 to 125 mg/kg/day. Systemic effects observed in 
the offspring were seen in the liver (hepatocyte hypertrophy and eosinophilia) and eye (infantile glaucoma).  Body tremors were observed in the parents 
and offspring at 125 mg/kg/day.  No teratogenic effects, maternal toxicity or fetotoxicity were observed in rats and rabbits administered 200 and 400 
mg/kg/day, respectively, of permethrin. 
Piperonyl Butoxide:  Teratogenicity was reported in a rabbit study.  Fetotoxicity (fetal deaths and reduced body weights) and teratogenicity (limb 
deformity and decreased digits) were observed in mice and rats given oral dosages as high as 1800 mg/kg on days 9 through 11 of gestation.  Effects on 
litter sizes, pup survival, pup weights, and behavioral parameters were observed  in 1-,  2-, and 3-generation reproductive studies in rats and mice given 
dosages as high as 8000 mg/kg or 0.8% in the diet.  In addition, deviations in surface righting, olfactory orientation, cliff avoidance, and neurobehavioral 
changes were also noted in mice in subsequent generations.
 
MUTAGENICITY / GENOTOXICITY: 
Permethrin was negative in a bacterial mutagenicity study (Ames) and in a mammalian mutagenicity study (mouse lymphoma). 
Piperonyl Butoxide:  Not mutagneic in bacteria, silkworms, cultured mammalian cells, an Ames assay, and a dominant lethal test.  It was negative in an 
unscheduled DNA synthesis study and in a chromosome aberration study.  It induced sister chromatid exchanges in cultured Chinese hamster ovary 
cells in both the presence and absence of metabolic activation, and was positive in a mouse lymphoma assay with metabolic activation.  Equivocal 
results were noted in a point mutation assay without metabolic activation, and it was negative with activation.  
 
CARCINOGENICITY: 
Six carcinogenicity assays, three each in mice and rats, were conducted with permethrin.  No tumorigenicity was seen in rat studies.  However, species 
specific increases in pulmonary adenomas, a common benign tumor of mice with a high spontaneous background incidence, were seen in the three 
mouse studies.  In one of these studies, there was an increased incidence of pulmonary alveolar cell carcinomas and benign liver adenomas when 
permethrin was administered in the diet at 5,000 ppm. 
Piperonyl Butoxide:  Liver tumors were noted in rats given concentrations as high as 2.4% in the diet for nearly two years.  Hepatocellular carcinomas 
were induced in male mice administered concentrations as high as 1.2% in the diet for a year.  However, in other studies, no carcinogenic effects were 
noted in mice or rats.
  
 
SECTION 12. ECOLOGICAL INFORMATION
  
There are no data for the final product or its formulation(s).  The information presented below pertains to the following ingredient(s).
 
ECOTOXICITY DATA 
 
  
SYNERGIZED DELICE Pour-On Insecticide 
STUDY DESCRIPTION 
LD50 (rat) 
LD50 (rabbit) 
Eye Irritation (rabbit) 
Skin Irritation (rabbit) 
Skin Sensitization (guinea pig)
 
MSDS NUMBER: SP000915
RESULT 
> 5000 mg/kg 
> 2 mL/kg 
Slightly irritating 
Slightly irritating 
Not sensitizing
Latest Revision Date: 18-Nov-2005
PRODUCT / CHEMICAL NAME 
 Synergized Delice Pour-On Insecticide 
Ectiban Pour-On Insectcide 
Page 5 of 7 
Published Date:  18-Nov-2005
EXPOSURE ROUTE 
Oral 
Dermal 
Eye 
Skin
INGREDIENT ECOTOXICITY 
Permethrin:96-hr LC50 (rainbow  trout): 0.1 to 314 ug/L 
Permethrin: 96-hr LC50 (brook trout): 2.3 to 5.2 ug/L 
Permethrin: 96-hr LC50 (channel catfish): 1.1 ug/L 
Permethrin: 48-hr EC50 (daphnid): 0.2 to 22 ug/L  
Piperonyl Butoxide: 48-hr LC50 (ceriodaphnid): 330 ug/L  
Piperonyl Butoxide: 96-hr LC50 (bluegill): 4.2 ug/L 
Piperonyl Butoxide: 96-hr LC50 (rainbow trout): 3.4 ug/L
 
ENVIRONMENTAL DATA 
 
 
 
OTHER INGREDIENT ENVIRONMENTAL DATA: 
Permethrin is readily biodegradable. 
Piperonyl Butoxide is potentially biodegradable based on data from related 
chemicals.
 
ADDITIONAL ECOTOXICITY / ENVIRONMENTAL INFORMATION: 
This pesticide is extremely toxic to fish and aquatic organisms.
  
SECTION 13. DISPOSAL CONSIDERATIONS
  
MATERIAL WASTE:
Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations.  Incineration is the preferred method of disposal, when 
appropriate. Operations that involve the crushing or shredding of waste materials or returned goods must be handled to meet the recommended 
exposure limit(s).
 
PACKAGING AND CONTAINERS:
Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations.
  
SECTION 14. TRANSPORT INFORMATION
  
This material is not subject to the transportation regulations of DOT, ICAO, and the IMO.   Refer to site-specific procedures and requirements for 
additional guidance.
 
ADR CLASSIFICATION:
 
 
Proper Shipping Name:
Environmentally hazardous substance, liquid, n.o.s. (permethrin)
 
Hazard Class:
9
 
UN Number:
UN 3082
 
Packing Group:
III
 
Classification Code: 
M6
 
ADDITIONAL INFORMATION: 
Although this material is regulated only under the ADR, both the IATA and IMO have special provisions that allow the shipper to transport materials 
under the shipping name "Environmentally hazardous substance, liquid, n.o.s." if the material is being transported under both ADR and either IATA or 
IMO regulations.     
  
SECTION 15. REGULATORY INFORMATION
  
  
TSCA LISTING
CHEMICAL NAME
TSCA
Piperonyl Butoxide
Listed
Distillates, petroleum, solvent-refined light paraffinic
Listed
Distillates, petroleum, solvent-refined heavy paraffinic
Listed
 
U.S. STATE REGULATIONS
CHEMICAL NAME
California 
Proposition 65
CARTK
NJRTK
CTRTK
MARTK
Permethrin Technical
Substance no. 
3422    Listed.
Listed.
Piperonyl Butoxide
Substance no. 
3732    Listed.
Distillates, petroleum, solvent-refined light paraffinic
Listed.
 
Fields in the above tables that do not contain data indicate that those materials have not been listed by local regulations.
  
MSDS NUMBER: SP000915
SYNERGIZED DELICE Pour-On Insecticide 
Latest Revision Date: 18-Nov-2005
 
Page 6 of 7 
Published Date:  18-Nov-2005
 
 
SECTION 16. OTHER INFORMATION
  
Although reasonable care has been taken in the preparation of this document, we extend no warranties and make no representations as to the accuracy 
or completeness of the information contained therein, and assume no responsibility regarding the suitability of this information for the user's intended 
purposes or for the consequence of its use.  Each individual should make a determination as to the suitability of the information for their particular 
purpose(s).
 
The trademarks indicated by CAPITAL LETTERS in this [M]SDS are the property of, licensed to, promoted or distributed by Schering-Plough 
Corporation, its subsidiaries or related companies.
 
DEPARTMENT ISSUING MSDS:
Global Safety and Environmental Affairs 
Occupational and Environmental Toxicology 
Schering-Plough Corporation 
1095 Morris Avenue 
Union, NJ 07083 USA
 
SCHERING-PLOUGH MSDS HELPLINE:
(800) 770-8878 (US and Canada) 
(908) 629-3657 (Worldwide) 
Monday to Friday, 9am to 5pm (US Eastern Time) 
 
MSDS CREATION DATE:
14-Aug-1998
SUPERSEDES DATE:
29-Jul-2005
  
  
MSDS NUMBER: SP000915
SYNERGIZED DELICE Pour-On Insecticide 
Latest Revision Date: 18-Nov-2005
 
Page 7 of 7 
Published Date:  18-Nov-2005