Eric Courchesne, PhD
Heather J. Chisum, BA
Jeanne Townsend, PhD
Angilene Cowles, BA
James Covington, MA
Brian Egaas, MS
Mark Harwood, BA
Stuart Hinds, MD
Gary A. Press, MD
Index terms:
Aging
Brain, growth and development,
10.91
Brain, MR, 10.121411, 10.12142
Brain, volume, 10.91
Magnetic resonance (MR), volume
measurement, 10.121411,
10.12142
Radiology 2000; 216:672–682
Abbreviations:
CSF 5 cerebrospinal fluid
GM 5 gray matter
IQ 5 intelligence quotient
WM 5 white matter
1 From the Laboratory for Research on
the Neuroscience of Autism, Chil-
dren’s Hospital Research Center, 8110
La Jolla Shores Dr, Suite 201, La Jolla,
CA 92037 (E.C., H.J.C., J.T., A.C., J.C.,
B.E., M.H., S.H.); the Department of
Neurosciences, School of Medicine,
University of California at San Diego,
La Jolla (E.C., J.T.); and the Kaiser Per-
manente Hospital, San Diego, Calif
(G.A.P.). Received April 5, 1999; revi-
sion requested June 7; final revision
received December 7; accepted De-
cember 21. This work is supported by
funds from NINDS (2-RO1-NS-19855)
awarded to Eric Courchesne and
NINDS (5RO1-NS-34155) award to
Jeanne Townsend. Address corre-
spondence to E.C. (e-mail: ecourchesne
@ucsd.edu).
© RSNA, 2000
Author contributions:
Guarantor of integrity of entire study,
E.C.; study concepts, E.C., G.A.P.; study
design, E.C.; definition of intellectual
content, E.C.; literature research, E.C.,
H.J.C.; clinical studies, B.E., S.H.; data
acquisition, J.T., J.C., E.C., A.C.; data
analysis, H.J.C., A.C., B.E.; statistical
analysis, J.T., M.H.; manuscript prepara-
tion, E.C., H.J.C., G.A.P., J.T.; manu-
script editing, E.C., G.A.P., H.J.C.;
manuscript review, E.C., G.A.P.
Normal Brain Development
and Aging: Quantitative
Analysis at in Vivo MR
Imaging in Healthy
Volunteers1
PURPOSE: To quantitate neuroanatomic parameters in healthy volunteers and to
compare the values with normative values from postmortem studies.
MATERIALS AND METHODS: Magnetic resonance (MR) images of 116 volunteers
aged 19 months to 80 years were analyzed with semiautomated proce