Endogen Recombinant Proteins 45 RBOIFNGI RBOIFNGIS RBOIL1BI RBOIL2I RBOIL4I RBOIL8I RBOTNFAI RBOTNFAIS RCIL6I RCTNFAI REIL2I REIL4I REIL8I RETNFAI RFGFB50 RFIL2I RFIL6I RFTNFAI RGCSF10 RGMCSF10 RGMCSF2 RIFNG100 RIFNG50 RIL1025 RIL105 RIL1110 RIL1325 RIL135 RIL155 RIL1720 RIL1AI RIL1BI RIL250 RIL2I RIL4I RIL4MI RIL510 RIL6I RIL75 RMCP120 RMGMCSF10 RMIP1A20 RMIL105 RMIL1B5 RMIL1BI RMIL2I RMIL310 RMIL4I RMIL6I RMKCI RMTNFAI RPIFNGI RPIL1BI RPIL4I RPIL6I RPIL8I RPIL12P40I RPIL12I RPTNFAI RRIL18I RRIL2I RRIL410 RRIL65 RRMCP110 RRMIL18I RRMIP1A10 RRNTS20 RRTNFAI RSCF10 RTNFAI RTNFAIS RTNFB20 RVEGF10 RVEGFI 4/20/2009. 4/20/2009. Material Safety Data Sheet Product name Manufacturer Product No. MSDS # Validation date Print date In case of emergency Product and company identification Responsible name MSDS (Regulatory Affairs) : : : : : : : 1 . CHEMTREC: 800.424.9300 OUTSIDE US: 202.483.7616 Supplier : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 Use of Substance/Preparation Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 800.874.3723 Part of Thermo Fisher Scientific Dermal contact. Eye contact. Inhalation. Ingestion. Emergency overview Hazards identification Routes of entry Potential acute health effects Slightly irritating to the respiratory system. No known significant effects or critical hazards. Slightly irritating to the skin. Skin Inhalation Ingestion Physical state Solid. [Powder.] MAY CAUSE RESPIRATORY TRACT, EYE AND SKIN IRRITATION. Slightly irritating to the eyes, skin and respiratory system. Handling and/or processing of this material may generate a dust which can cause mechanical irritation of the eyes, skin, nose and throat. Avoid breathing dust. Avoid contact with eyes. Avoid prolonged or repeated contact with skin. Use only with adequate ventilation. Keep container tightly closed and sealed until ready for use. Wash thoroughly after handling. : : : : : : OSHA/HCS status : While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200), this MSDS contains valuable information critical to the safe handling and proper use of the product. This MSDS should be retained and available for employees and other users of this product. 2 . 1/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Hazards identification 2 . Slightly irritating to the eyes. Eyes See toxicological information (section 11) : Medical conditions aggravated by over- exposure None known. : Potential chronic health effects Carcinogenicity : No known significant effects or critical hazards. Mutagenicity : No known significant effects or critical hazards. Teratogenicity : No known significant effects or critical hazards. Developmental effects : No known significant effects or critical hazards. Chronic effects : No known significant effects or critical hazards. Fertility effects : No known significant effects or critical hazards. Over-exposure signs/symptoms Ingestion : No specific data. Skin : Adverse symptoms may include the following: irritation redness Eyes : Adverse symptoms may include the following: irritation watering redness Inhalation : Adverse symptoms may include the following: respiratory tract irritation coughing The substance is not classified as dangerous according to Directive 67/548/EEC and its amendments. Classification Not classified. : Endogen Recombinant Proteins (Bulk) 98 - 100 Composition/information on ingredients Name CAS number % United States 3 . There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Substance/preparation Substance : Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to- mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. First aid measures Inhalation : 4 . 2/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins First aid measures 4 . Wash out mouth with water. Remove dentures if any. Move exposed person to fresh air. Keep person warm and at rest. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Eye contact Skin contact Ingestion : : : Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. See section 11 for more detailed information on health effects and symptoms. Use an extinguishing agent suitable for the surrounding fire. Fire-fighting measures Extinguishing media Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. No specific fire or explosion hazard. Special protective equipment for fire-fighters Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. : 5 . Special exposure hazards : None known. Suitable : Not suitable : Hazardous combustion products : No specific data. Flammability of the product : No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Avoid breathing dust. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment (see section 8). Move containers from spill area. Approach release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Vacuum or sweep up material and place in a designated, labeled waste container. Avoid creating dusty conditions and prevent wind dispersal. Dispose of via a licensed waste disposal contractor. Note: see section 1 for emergency contact information and section 13 for waste disposal. Environmental precautions Accidental release measures : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Personal precautions : Large spill : 6 . 3/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Accidental release measures 6 . Move containers from spill area. Vacuum or sweep up material and place in a designated, labeled waste container. Dispose of via a licensed waste disposal contractor. Small spill : Do not store above the following temperature: 2 to 8°C (35.6 to 46.4°F). Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Put on appropriate personal protective equipment (see section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Do not breathe dust. Do not ingest. Avoid contact with eyes, skin and clothing. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Handling and storage Handling Storage : : 7 . Exposure controls/personal protection Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If operating conditions cause high dust concentrations to be produced, use dust goggles. Personal protection Eyes Respiratory Consult local authorities for acceptable exposure limits. : : Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Hands : 8 . Engineering measures : Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Recommended monitoring procedures : If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Europe No exposure limit value known. 4/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Exposure controls/personal protection 8 . Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Skin : Environmental exposure controls : Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. Solid. [Powder.] Physical and chemical properties Physical state : 9 . The product is stable. Under normal conditions of storage and use, hazardous polymerization will not occur. No specific data. Under normal conditions of storage and use, hazardous decomposition products should not be produced. No specific data. Stability and reactivity Chemical stability Conditions to avoid Incompatible materials Hazardous decomposition products : : : : 10 . Toxicological information United States 11 . Acute toxicity Conclusion/Summary : To the best of our knowledge, the toxicological properties of this substance have not been thoroughly investigated. Chronic toxicity Conclusion/Summary : Not available. Carcinogenicity Conclusion/Summary : Not available. Mutagenicity Conclusion/Summary : Not available. Teratogenicity Conclusion/Summary : Not available. Reproductive toxicity Repeated or prolonged inhalation of dust may lead to chronic respiratory irritation. Chronic effects : No known significant effects or critical hazards. Carcinogenicity : No known significant effects or critical hazards. Mutagenicity No known significant effects or critical hazards. Teratogenicity Developmental effects : No known significant effects or critical hazards. Fertility effects : No known significant effects or critical hazards. : : Europe Not available. Conclusion/Summary : 5/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Ecological information United States Environmental effects : No known significant effects or critical hazards. 12 . Aquatic ecotoxicity Conclusion/Summary : Not available. Other adverse effects : No known significant effects or critical hazards. The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Waste disposal Disposal considerations Disposal should be in accordance with applicable regional, national and local laws and regulations. : 13 . Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Hazardous waste : Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC. Transport information - DOT Classification - - - Not regulated. IATA-DGR Class - Regulatory information UN number Proper shipping name Classes PG* - Not regulated. 14 . PG* : Packing group Not regulated. HCS Classification Regulatory information U.S. Federal regulations United States inventory (TSCA 8b): Not determined. Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean Air Act (CAA) 112 accidental release prevention: No products were found. Clean Air Act (CAA) 112 regulated flammable substances: No products were found. Clean Air Act (CAA) 112 regulated toxic substances: No products were found. WHMIS (Canada) Not controlled under WHMIS (Canada). SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found. : : : Canada United States 15 . 6/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Regulatory information 15 . CEPA Toxic substances: None of the components are listed. Canadian ARET: None of the components are listed. Canadian NPRI: None of the components are listed. Alberta Designated Substances: None of the components are listed. Ontario Designated Substances: None of the components are listed. Quebec Designated Substances: None of the components are listed. Australia inventory (AICS): Not determined. China inventory (IECSC): Not determined. Korea inventory (KECI): Not determined. Philippines inventory (PICCS): Not determined. Japan inventory (ENCS): Not determined. International regulations International lists : EU regulations Canadian lists : Canada inventory : Canada inventory: Not determined. This product is not classified according to EU legislation. Risk phrases : : Other information Hazardous Material Information System (U.S.A.) 1 0 0 0 0 1 National Fire Protection Association (U.S.A.) Health Special Instability Flammability Health Flammability Physical hazards MAY CAUSE RESPIRATORY TRACT, EYE AND SKIN IRRITATION. Label requirements : Notice to reader Date of printing Date of issue Date of previous issue Version 4/20/2009. 4/20/2009. 1.05 7/22/2008. : : : : : : 16 . The customer is responsible for determining the PPE code for this material. Indicates information that has changed from previously issued version. 7/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax Endogen Recombinant Proteins Other information 16 . To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the information required by the CPR. 8/8 4/20/2009. Biosciences Division 3747 N. Meridian Rd. Rockford, IL (815) 968-0747 www.thermo.com/pierce Pierce PO Box 117 61105 (815) 968-7316 Fax