DOSE-DEPENDENT SYSTEMIC AND RENAL HAEMODYNAMIC EFFECTS
OF ANGIOTENSIN II (ANG II) IN CONSCIOUS LAMBS:
ROLE OF AT1 AND AT2 RECEPTORS
by
Mona Lynne Chappellaz
Francine Gabriel Smith
from
Departments of Physiology & Biophysics/Medicine
University of Calgary
Calgary, Alberta, T2N 4N1
CANADA
Running Title:
ANG II and the developing newborn
Address for correspondence:
Francine G. Smith, Ph.D.
Professor
Department of Physiology & Biophysics
Faculty of Medicine
University of Calgary
3330 Hospital Drive, NW
Calgary, Alberta, T2N 4N1
CANADA
Telephone:
(403)220-4090
Email:
fsmith@ucalgary.ca
Physiology in Press; published online on August 9, 2005 as 10.1113/expphysiol.2005.031195
Copyright 2005 by The Physiological Society
) by guest on December 9, 2009
ep.physoc.org
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ABSTRACT
The present experiments were designed to measure the effects of acute
administration of ANG II on mean arterial pressure (MAP) and renal blood flow (RBF) in
conscious, chronically instrumented lambs at two different stages of postnatal maturation,
and to determine the receptors through which these effects of ANG II are elicited.
Experiments consisted of haemodynamic measurements for 10 seconds before (Control)
and for sixty sec after intravenous (I.V.) administration of one of 11 doses of ANG II (0
to 200 ng·kg-1). Administration of ANG II was associated with a