Bradley E. Chipps
ALLERGEN-IMPERMEABLE BED COVERS FOR ADULTS WITH
CONTROL OF EXPOSURE TO MITE ALLERGEN AND
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Purpose of the Study. Allergy to house dust mite (HDM)
is an important contributor to childhood asthma, and these
investigators sought to determine whether the use of mat-
tress and pillow encasings resulted in effective long-term
control of mattress HDM levels, thus reducing the need for
maintenance asthma medication.
The subjects were 60 children (5–15
years of age) with asthma and HDM allergy, in the absence
of any other clinically relevant allergy. Inclusion criteria
included physician-diagnosed asthma, positive HDM
puncture skin test results, positive HDM bronchoprovoca-
tion results, and total HDM concentrations of 2000 ng/g
dust from the child’s mattress. All except 4 of the study
patients were treated with inhaled corticosteroids.
In this prospective, double-blind, placebo-
controlled, 1-year study, children were randomized to the
use of active (allergy control) or placebo mattress and
pillow encasings. Baseline measures included mattress
dust sampling, spirometry, and adjustment of medications.
Symptom scores and peak flows were recorded through-
out the study. Clinical assessments, including medication
adjustments, and dust sampling were performed every