Ether AETHER; ANAESTHETIC ETHER; ANESTHESIA ETHER; ANESTHETIC ETHER; DIAETHYLAETHER (GERMAN); DIETHYL ETHER; DIETHYL OXIDE; DWUETYLOWY ETER (POLISH); ETERE ETILICO (ITALIAN); ETHER; ETHER (DOT); ETHER, ETHYL (DOT); ETHER ETHYLIQUE (FRENCH); ETHOXYETHANE; ETHYL ETHER; OXYDE D'ETHYLE (FRENCH); SOLVENT ETHER; SULFURIC ETHER; ETHANE, 1,1'-OXYBIS- 857 1879550 5/16/2008. 5/16/2008. Material Safety Data Sheet Product name Synonym Manufacturer Product No. MSDS # Validation date Print date In case of emergency Product and company identification Responsible name MSDS (Regulatory Affairs) Ether : : : : : : : : 1 . Chemical formula : C4H10O CHEMTREC: 800.424.9300 OUTSIDE US: 202.483.7616 Supplier : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 or 800.874.3723 : Use of Substance/Preparation Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. : Thermo Fisher Scientific Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 United States 815.968.0747 800.874.3723 Dermal contact. Eye contact. Inhalation. Ingestion. Emergency overview Hazards identification Routes of entry Potential acute health effects No known significant effects or critical hazards. May cause eye irritation. Harmful if swallowed. May cause skin irritation. Eyes Skin Inhalation Ingestion Physical state Liquid. [COLORLESS LIQUID WITH A CHARACTERISTIC PUNGENT, SWEETISH ODOR. [NOTE: A GAS ABOVE 94 F.]] DANGER ! EXTREMELY FLAMMABLE LIQUID AND VAPOR. FLAMMABLE. VAPOR MAY CAUSE FLASH FIRE. MAY BE HARMFUL IF SWALLOWED. CAN CAUSE TARGET ORGAN DAMAGE. Extremely flammable liquid. Harmful if swallowed. Keep away from heat, sparks and flame. Do not ingest. Avoid breathing vapor or mist. Avoid contact with eyes, skin and clothing. Can cause target organ damage. Use only with adequate ventilation. Keep container tightly closed and sealed until ready for use. Wash thoroughly after handling. : : : : : : : Odor : Characteristic. Pungent. Sweetish. OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). 2 . Potential chronic health effects Carcinogenicity : No known significant effects or critical hazards. Chronic effects : Can cause target organ damage. 1/9 5/16/2008. Ether Hazards identification 2 . See toxicological information (section 11) Medical conditions aggravated by over- exposure Pre-existing digestive disorders and disorders involving any other target organs mentioned in this MSDS as being at risk may be aggravated by over-exposure to this product. : Mutagenicity : No known significant effects or critical hazards. Teratogenicity : No known significant effects or critical hazards. Developmental effects : No known significant effects or critical hazards. Fertility effects : No known significant effects or critical hazards. Over-exposure signs/symptoms Ingestion : No specific data. Skin : No specific data. Eyes : No specific data. Inhalation : No specific data. Target organs : Causes damage to the following organs: mucous membranes, upper respiratory tract, skin, eyes, central nervous system (CNS), eye, lens or cornea. The substance is classified as dangerous according to Directive 67/548/EEC and its amendments. Classification F+; R12 R19 Xn; R22 R66, R67 : Physical/chemical hazards : Extremely flammable. May form explosive peroxides. Human health hazards : Harmful if swallowed. Repeated exposure may cause skin dryness or cracking. Vapors may cause drowsiness and dizziness. Ether 60-29-7 98 - 100 Composition/information on ingredients Name CAS number % United States 3 . There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Substance/preparation Substance : Ingredient name CAS number % Classification EC number Ether 60-29-7 98 - 100 200-467-2 F+; R12 R19 Xn; R22 R66, R67 [1] [2] Europe [1] Substance classified with a health or environmental hazard [2] Substance with a workplace exposure limit Occupational exposure limits, if available, are listed in section 8. 2/9 5/16/2008. Ether Wash out mouth with water. Remove dentures if any. Move exposed person to fresh air. Keep person warm and at rest. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to- mouth resuscitation. Get medical attention. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. First aid measures Eye contact Skin contact Inhalation Ingestion : : : : 4 . Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. See section 11 for more detailed information on health effects and symptoms. Use dry chemical, CO2, water spray (fog) or foam. Fire-fighting measures Extinguishing media Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion. The vapor/gas is heavier than air and will spread along the ground. Vapors may accumulate in low or confined areas or travel a considerable distance to a source of ignition and flash back. Runoff to sewer may create fire or explosion hazard. Special protective equipment for fire-fighters Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. : 5 . Special exposure hazards : Do not use water jet. Suitable : Not suitable : Hazardous combustion products : Decomposition products may include the following materials: carbon oxides Flammability of the product : No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapor or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment (see section 8). Environmental precautions Accidental release measures : Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Personal precautions : 6 . 3/9 5/16/2008. Ether Accidental release measures 6 . Stop leak if without risk. Move containers from spill area. Approach release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see section 13). Use spark-proof tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilled product. Note: see section 1 for emergency contact information and section 13 for waste disposal. Large spill : Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble or absorb with an inert dry material and place in an appropriate waste disposal container. Use spark-proof tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor. Small spill : Do not store above the following temperature: -20°C (-4°F). Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see section 10) and food and drink. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Put on appropriate personal protective equipment (see section 8). Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Do not breathe vapor or mist. Do not ingest. Avoid contact with eyes, skin and clothing. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use non-sparking tools. Take precautionary measures against electrostatic discharges. To avoid fire or explosion, dissipate static electricity during transfer by grounding and bonding containers and equipment before transferring material. Empty containers retain product residue and can be hazardous. Do not reuse container. Handling and storage Handling Storage : : 7 . diethyl ether ACGIH (United States, 0/2000). TWA: 400 ppm STEL: 500 ppm OSHA (United States, 0/1989). TWA: 400 ppm STEL: 500 ppm ACGIH TLV (United States, 1/2007). STEL: 1520 mg/m³ 15 minute(s). STEL: 500 ppm 15 minute(s). TWA: 1210 mg/m³ 8 hour(s). TWA: 400 ppm 8 hour(s). OSHA PEL (United States, 11/2006). TWA: 1200 mg/m³ 8 hour(s). TWA: 400 ppm 8 hour(s). Exposure controls/personal protection Product name Exposure limits United States 8 . 4/9 5/16/2008. Ether Exposure controls/personal protection 8 . OSHA PEL 1989 (United States, 3/1989). STEL: 1500 mg/m³ 15 minute(s). STEL: 500 ppm 15 minute(s). TWA: 1200 mg/m³ 8 hour(s). TWA: 400 ppm 8 hour(s). Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Personal protection Eyes Skin Respiratory Consult local authorities for acceptable exposure limits. : : : Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Hands : Engineering measures : Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapor or dust concentrations below any lower explosive limits. Use explosion-proof ventilation equipment. Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Recommended monitoring procedures : If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Environmental exposure controls : Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. Europe diethyl ether EU OEL (Europe, 5/2006). Notes: Indicative short term: 616 mg/m³ 15 minute(s). short term: 200 ppm 15 minute(s). 8 hours: 308 mg/m³ 8 hour(s). 8 hours: 100 ppm 8 hour(s). Liquid. [COLORLESS LIQUID WITH A CHARACTERISTIC PUNGENT, SWEETISH ODOR. [NOTE: A GAS ABOVE 94 F.]] Colorless. Physical and chemical properties Physical state Color : : Flash point : Closed cup: -45.1°C (-49.2°F) 180°C (356°F) : Auto-ignition temperature Flammable limits : Lower: 1.9% Upper: 36% 9 . 5/9 5/16/2008. Ether Physical and chemical properties 9 . 35.05°C (95.1°F) -116.06°C (-176.9°F) 0.7135 2.55 [Air = 1] 58.9 kPa (442 mm Hg) Partially soluble in the following materials: cold water and hot water. 74.1 g/mole Characteristic. Pungent. Sweetish. Boiling/condensation point Melting/freezing point 11.8 ((n-BUTYL ACETATE=1) = 1) Molecular weight Relative density Vapor pressure Vapor density Evaporation rate Solubility Odor C4H10O Molecular formula : : : : : : : : : : Octanol/water partition coefficient : 0.82 The product is stable. Under normal conditions of storage and use, hazardous polymerization will not occur. Highly reactive or incompatible with the following materials: oxidizing materials Will not occur. Under normal conditions of storage and use, hazardous decomposition products should not be produced. Avoid all possible sources of ignition (spark or flame). Do not pressurize, cut, weld, braze, solder, drill, grind or expose containers to heat or sources of ignition. Do not allow vapor to accumulate in low or confined areas. Stability and reactivity Chemical stability Conditions to avoid Incompatible materials Hazardous decomposition products Possibility of hazardous reactions : : : : : 10 . Toxicological information United States 11 . Acute toxicity diethyl ether LD50 Dermal Rabbit >20 mL/kg - LD50 Oral Rat 1215 mg/kg - Product/ingredient name Result Species Dose Exposure Conclusion/Summary : Not available. Chronic toxicity Conclusion/Summary : Not available. Carcinogenicity Conclusion/Summary : Not available. Mutagenicity Conclusion/Summary : Not available. Teratogenicity Conclusion/Summary : Not available. Reproductive toxicity Classification diethyl ether - 3 - None. - - Product/ingredient name ACGIH EPA NIOSH NTP IARC OSHA Europe Not available. Conclusion/Summary : 6/9 5/16/2008. Ether Toxicological information 11 . IDLH : 1900 ppm Prolonged or repeated contact can defat the skin and lead to irritation, cracking and/or dermatitis. Chronic effects : No known significant effects or critical hazards. Carcinogenicity : No known significant effects or critical hazards. Mutagenicity No known significant effects or critical hazards. Teratogenicity Developmental effects : No known significant effects or critical hazards. Fertility effects : No known significant effects or critical hazards. : : Ecological information United States Octanol/water partition coefficient : 0.82 Environmental effects : This product shows a low bioaccumulation potential. Bioconcentration factor : Not available. 12 . Aquatic ecotoxicity Conclusion/Summary : Not available. The generation of waste should be avoided or minimized wherever possible. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Code: F039 Waste disposal Waste stream Disposal considerations Disposal should be in accordance with applicable regional, national and local laws and regulations. : : 13 . Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION for additional handling information and protection of employees. Hazardous waste : The classification of the product may meet the criteria for a hazardous waste. Transport information 3 DOT Classification DIETHYL ETHER OR ETHYL ETHER I DIETHYL ETHER UN1155 IATA-DGR Class 3 Regulatory information UN number Proper shipping name Classes PG* I UN1155 14 . PG* : Packing group Flammable liquid Target organ effects HCS Classification Regulatory information U.S. Federal regulations TSCA 8(a) PAIR: diethyl ether TSCA 8(a) IUR: diethyl ether United States inventory (TSCA 8b): This material is listed or exempted. TSCA 12(b) annual export notification: diethyl ether : : United States 15 . 7/9 5/16/2008. Ether Regulatory information 15 . Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean Air Act (CAA) 112 accidental release prevention: diethyl ether Clean Air Act (CAA) 112 regulated flammable substances: diethyl ether Clean Air Act (CAA) 112 regulated toxic substances: No products were found. CEPA Toxic substances: This material is not listed. Canadian ARET: This material is not listed. Canadian NPRI: This material is not listed. Alberta Designated Substances: This material is not listed. Ontario Designated Substances: This material is not listed. Quebec Designated Substances: This material is not listed. Australia inventory (AICS): This material is listed or exempted. China inventory (IECSC): This material is listed or exempted. Korea inventory (KECI): This material is listed or exempted. Philippines inventory (PICCS): This material is listed or exempted. Japan inventory (ENCS): This material is listed or exempted. WHMIS (Canada) Class B-2: Flammable liquid International regulations International lists SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: diethyl ether SARA 311/312 MSDS distribution - chemical inventory - hazard identification: diethyl ether: Fire hazard, Immediate (acute) health hazard, Delayed (chronic) health hazard : : Canada EU regulations Canadian lists : Canada inventory : Canada inventory: This material is listed or exempted. R12- Extremely flammable. R19- May form explosive peroxides. R22- Harmful if swallowed. R66- Repeated exposure may cause skin dryness or cracking. R67- Vapors may cause drowsiness and dizziness. Hazard symbol or symbols Risk phrases : : Extremely flammable, Harmful : Other information Hazardous Material Information System (U.S.A.) 1 4 1 Health Flammability Physical hazards EXTREMELY FLAMMABLE LIQUID AND VAPOR. FLAMMABLE. VAPOR MAY CAUSE FLASH FIRE. MAY BE HARMFUL IF SWALLOWED. CAN CAUSE TARGET ORGAN DAMAGE. Label requirements : : 16 . 8/9 5/16/2008. Ether Other information 16 . 1 4 1 National Fire Protection Association (U.S.A.) Health Special Instability Flammability Notice to reader To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. Date of printing Date of issue Date of previous issue Version 5/16/2008. 5/16/2008. 1.01 No previous validation. : : : : : The customer is responsible for determining the PPE code for this material. Indicates information that has changed from previously issued version. Full text of R-phrases referred to in sections 2 and 3 - Europe : R12- Extremely flammable. R19- May form explosive peroxides. R22- Harmful if swallowed. R66- Repeated exposure may cause skin dryness or cracking. R67- Vapors may cause drowsiness and dizziness. Full text of classifications referred to in sections 2 and 3 - Europe : F+ - Extremely flammable Xn - Harmful This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the information required by the CPR. 9/9 5/16/2008.